Results 191 to 200 of about 2,071,977 (304)

Impact of Aspirin Use on Mortality and Cardiac Allograft Vasculopathy After Heart Transplantation: A Systematic Review and Meta-analysis. [PDF]

open access: yesClin Transplant
Fournier N   +12 more
europepmc   +1 more source

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

open access: yesAdvanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng   +10 more
wiley   +1 more source

Engineered Chiral Probiotics Ameliorate MASH via Gut–Liver Axis

open access: yesAdvanced Science, EarlyView.
A chiral gold nanozyme was coated onto the gut commensal bacterium Faecalibacterium duncaniae (F. duncaniae) to create an engineered probiotic. In mouse models of MASH, this orally administered living therapeutic protected the bacterium against oxidative stress, enhanced its gut colonization, reversed steatosis, inflammation, and fibrosis, and improved
Jing Chen   +12 more
wiley   +1 more source

Spiked Helmet Sign in the Early Post-Heart Transplantation Period: A Dramatic STEMI Mimic in a Structurally Normal Donor Heart. [PDF]

open access: yesAnn Noninvasive Electrocardiol
Lima DRM   +5 more
europepmc   +1 more source

Combined Immune‐Peptide Nanofiber with HSP70/AKT/mTOR Axis Blockade Enhances Photothermal Immunotherapy, Inhibiting Tumor Growth and Recurrence

open access: yesAdvanced Science, EarlyView.
A carrier‐free peptide‐guided PSP@IR‐CF3 nanofiber system integrates PD‐L1 targeting and photothermal immunotherapy for enhanced cancer treatment. By revealing PTIT‐induced activation of the HSP70/AKT/mTOR pathway and incorporating mTOR inhibition, this strategy effectively overcomes therapeutic resistance and prevents tumor recurrence, providing a ...
Xinyu Zhang   +11 more
wiley   +1 more source

From innovation to implementation: expanding global access to mechanical circulatory support and heart transplantation. [PDF]

open access: yesFront Cardiovasc Med
Alhuneafat L   +14 more
europepmc   +1 more source

NDFIP2 Suppresses Colorectal Cancer Metastasis Through DDX3X‐Dependent R‐Loop Remodeling and GNG13 Transcriptional Activation

open access: yesAdvanced Science, EarlyView.
NDFIP2 recruits NEDD4 to promote K48‐linked ubiquitination and proteasomal degradation of DDX3X, leading to R‐loop accumulation and CTCF‐dependent suppression of GNG13 transcription. Consequently, PI3K/AKT signaling, EMT, stemness, and colorectal cancer metastasis are inhibited.
Enjian Zhang   +12 more
wiley   +1 more source

Beating heart transplantation after normothermic machine perfusion: A single institution experience. [PDF]

open access: yesJTCVS Open
Kesseli SJ   +8 more
europepmc   +1 more source

Home - About - Disclaimer - Privacy