Immune Shielding of Human Heart Valves:A Proof-of-Concept Study of HLA-Targeting Therapy for Transplantations [PDF]
Children born with defective heart valves require multiple donor valve replacements throughout life, because these cannot grow and can cause early failure through immune degeneration. This study tests the lentiviral delivery of viral immune evasion genes
Bouten, Carlijn V.C.+9 more
core +1 more source
Prognostic factors for heart valve surgery outcomes in Dr Sardjito General Hospital Yogyakarta, Indonesia [PDF]
Heart valve disease is a serious health probem due its significant effect on mortality.Surgical intervention plays an importan roleinthe management of moderate to the severe valvular heart disease.
Priyatno, Wahyu, Supomo, .
core +1 more source
This work presents a method to print multi‐layer elastomer structures containing liquid cavities, where the fluid is incorporated as part of the printing process by freezing it, thus avoiding the conventional final filling step. We demonstrate this process by fabricating and characterizing dense arrays of zipping electrostatic actuators.
Giulio Grasso+2 more
wiley +1 more source
Estimation of Cardiac Valve Annuli Motion with Deep Learning [PDF]
Valve annuli motion and morphology, measured from non-invasive imaging, can be used to gain a better understanding of healthy and pathological heart function. Measurements such as long-axis strain as well as peak strain rates provide markers of systolic function.
arxiv
Tough and Fast Thermoresponsive Hydrogel Soft Actuators
This work develops tough, fast‐responding thermoresponsive double‐network hydrogels that combine excellent mechanical strength with rapid actuation. Composed of PNIPAm and ether‐based polyurethane, the hydrogels achieve ≈8 MPa compressive stress and ≈30% contractile stroke within 2 min at 50 °C, enabling temperature‐responsive fluid flow switching for ...
Xi Zhang, Shazed Aziz, Zhonghua Zhu
wiley +1 more source
Natural biomaterials in the management of the aortic valve pathology. Biomedical and clinical aspects: A review [PDF]
Heart valve diseases are a prevalent cardiovascular pathology worldwide, affecting nearly 2.5% of the population. Degenerative aortic stenosis is the most common form of heart valve disease.
Mokryk, Igor+5 more
core +2 more sources
Future of heart valve surgery [PDF]
In highly developed nations, valve surgery will be increasing applied in older people, with more co-morbidities and a higher incidence of concomitant coronary artery disease. Valve surgeons will be facing increased competition from the catheter-based procedures, both for valve repair and replacement; these are already applied clinically, and their ...
openaire +6 more sources
Computational methods for the aortic heart valve and its replacements
Introduction: Replacement with a prosthetic device remains a major treatment option for the patients suffering from heart valve disease, with prevalence growing resulting from an ageing population. While the most popular replacement heart valve continues
Rana Zakerzadeh, M. Hsu, M. Sacks
semanticscholar +1 more source
Miniaturized Devices for On‐the‐Spot Generation of Small‐Diameter Vascular Grafts
An intracorporeal extrusion device is developed for on‐the‐spot generation of vascular grafts with tunable diameters spanning from 1 to 6 mm. The device uses biomimetic polymers and light, to promptly obtaining biocompatible and high‐burst pressure‐resistant grafts.
Deyanira Hernandez‐Sanchez+11 more
wiley +1 more source
Stochastic Modelling and Dynamic Analysis of Cardiovascular System with Rotary Left Ventricular Assist Devices [PDF]
The left ventricular assist device (LVAD) has been used for end-stage heart failure patients as a therapeutic option. The aortic valve plays a critical role in heart failure and its treatment with LVAD. The cardiovascular-LVAD model is often used to investigate the physiological demands required by patients and predict the hemodynamic of the native ...
arxiv