Results 181 to 190 of about 2,810,461 (415)
Advanced Science, EarlyView.This study reveals a novel crosstalk between hepatic SREBP2‐mediated cholesterol biosynthesis pathway and peripheral lipoprotein lipase‐mediated lipolysis pathway in the regulation of systemic lipid metabolism. Notably, the lipid‐lowering effects of SREBP2 inhibition are independent of a functional LDL receptor, highlighting the potential of acute ...
Yifan Wang +13 more
wiley +1 more source
Genetic and phenotypic spectrum in the NONO‐associated syndromic disorder
American Journal of Medical Genetics Part A, Volume 191, Issue 2, Page 469-478, February 2023., 2023 Abstract The non‐POU domain‐containing octamer‐binding (NONO) protein is involved in multiple steps of gene regulation such as RNA metabolism and DNA repair. Hemizygous pathogenic variants in the NONO gene were confirmed to cause a rare X‐linked syndromic disorder. Through our in‐house diagnostics and subsequent matchmaking, we identified six unrelated
Franziska Roessler +21 more
wiley +1 more source
Transseptal BATMAN for High-Risk Valve-in-Ring Procedures
JACC: Case ReportsValve-in-ring procedures represent a feasible solution for high-risk patients with surgical repair failure. The risk of left ventricular outflow tract obstruction increases the challenge, and transcatheter approaches to prevent it are technically ...
Paolo Denti, MD +9 more
doaj
Fluid-structure interaction simulations of venous valves: a monolithic ALE method for large structural displacements [PDF]
arXiv, 2018 Venous valves are bicuspidal valves that ensure that blood in veins only flows back to the heart. To prevent retrograde blood flow, the two intraluminal leaflets meet in the center of the vein and occlude the vessel. In fluid-structure interaction (FSI) simulations of venous valves, the large structural displacements may lead to mesh deteriorations and
arxiv
The Journal of Thoracic and Cardiovascular Surgery, 2007 R.C. Quijano, James L. Cox
openaire +2 more sources
Advanced Science, EarlyView.Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin +15 more
wiley +1 more source
A Hollow Shell‐Lattice Soft Robot in Flexible Pipelines with Flowing Fluids
Advanced Science, EarlyView.This study proposes a novel shell‐lattice robot with hollow bodies, capable of crawling through pipes with flowing fluids of high velocities and viscosities and mixed with impurities. The robot also features capabilities of crawling with high payloads, in curved pipes, and unthethered crawling. These unique properties make this robot high promising for
Di Guo, Yiqiang Wang, Zhan Kang
wiley +1 more source
Development of a patient-specific finite element model of the Transcatheter Aortic Valve Implantation (TAVI) procedure [PDF]
arXiv, 2019 This work reports on a study to develop a patient-specific finite element model of the Transcatheter Aortic Valve Implantation procedure, using a model of a balloon-expandable percutaneous prosthetic aortic valve as a framework for the prediction of its performance.
arxiv
Hemorrhagic shock as a complication of anticoagulant therapy following the mitral valve replacement [PDF]
, 2007 This report describes a case of the hemorrhagic shock in a patient on the anticoagulant therapy supplementing implanted mechanical prosthetic heart valve replacing the mitral valve.
Dinko Tonković +5 more
core +1 more source
Advanced Science, EarlyView.Efficient R‐CHIP HR‐HPV Screening System: The R‐CHIP system utilizes the RPA/CRISPR method, a hand‐driven centrifugal microfluidic device, a smartphone micro‐imaging system, and the ResNet‐18 deep‐learning algorithm to simplify the sample detection process, ensure accurate results, and reduce costs.
Tao Xu +11 more
wiley +1 more source