Results 191 to 200 of about 2,810,461 (415)

The molecular genetics of RASopathies: An update on novel disease genes and new disorders

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 425-439, December 2022., 2022
Abstract Enhanced signaling through RAS and the mitogen‐associated protein kinase (MAPK) cascade underlies the RASopathies, a family of clinically related disorders affecting development and growth. In RASopathies, increased RAS‐MAPK signaling can result from the upregulated activity of various RAS GTPases, enhanced function of proteins positively ...
Marco Tartaglia, Yoko Aoki, Bruce D. Gelb   +2 more
wiley   +1 more source

2D Metalorganic Ferromagnets

Advanced Science, EarlyView.
The single‐layered 2D metalorganic coordination network Ni‐TCNE, made from Ni atoms and tetracyanoethylene molecules on a gold surface, is established as a ferromagnet with a high magnetic remanence and coercive field. Its Curie temperature is between 10 and 20 kelvin.
Egzona Isufi Neziri, Céline Hensky, Hien Quy Le, Diego Radillo Ochoa, Aleksandra Cebrat, Manfred Parschau, Karl‐Heinz Ernst, Christian Wäckerlin   +7 more
wiley   +1 more source

Clinical overview on RASopathies

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, Volume 190, Issue 4, Page 414-424, December 2022., 2022
Abstract RASopathies comprise a group of clinically overlapping developmental disorders caused by genetic variations affecting components or modulators of the RAS‐MAPK signaling cascade, which lead to dysregulation of signal flow through this pathway.
Martin Zenker
wiley   +1 more source

Rotational Atherectomy and Mechanical Support to Treat Left Main

JACC: Case Reports, 2019
We describe a complex percutaneous coronary intervention using rotational atherectomy (Rotablator, Boston Scientific, Marlborough, Massachusetts) and mechanical circulatory support (Impella, Abiomed, Danvers, Massachusetts) in a patient with multiple ...
Luis Augusto Palma Dallan, MD, Marcelo Harada Ribeiro, MD, Chinedu Igwe, MD, Gabriel Tensol Pereira Rodrigues, MD, Elder Iarossi Zago, MD, Vladislav Zimin, MD, PhD, Armando Vergara-Martel, MS, Marco Costa, MD, PhD, Guilherme Ferragut Attizzani, MD, Mehdi Shishehbor, DO, MPH, PhD, Hiram Grando Bezerra, MD, PhD   +10 more
doaj  

Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ‐PIAS1‐5/miR‐219a‐2‐3p/TEAD1 Axis

Advanced Science, EarlyView.
A model is schematically represented for the major molecular mechanisms by which homocysteine (Hcy) accelerates the nuclear export of circ‐PIAS1‐5, which regulates atherosclerosis by acting as a competing endogenous RNA for miR‐219a‐2‐3p. Hcy enrichment of circ‐PIAS1‐5 leads to YTHDC1 binding to circ‐PIAS1‐5 and promotes its intracellular localization ...
Shengchao Ma, Fei Ma, Ning Ding, Lin Xie, Anning Yang, Jiangyong Shen, Yun jiao, Kai Wu, YueE Chai, Zhigang Bai, Jiantuan Xiong, Nan Li, Huiping Zhang, Yideng Jiang   +13 more
wiley   +1 more source

Evidence for a mitral valve origin of the left ventricular third heart sound. [PDF]

, 1969
John Fleming
openalex   +1 more source

Resilient and Flexible Electrohydrodynamics Pumps for Human–Machine Interfaces

Advanced Science, EarlyView.
This study introduces resilient and flexible electrohydrodynamic (EHD) pumps designed to enhance human–machine interfaces. These pumps are both quiet and compact, featuring a unique electrode configuration that overcomes the typical limitations associated with dielectric breakdowns and subsequent permanent failures.
Yu Kuwajima, Amr Marzuq, Soraya Segawa, Yuya Yamaguchi, Yuhei Yamada, Takafumi Morita, Katrene Morozov, Haruto Iwasaki, Sota Suzuki, Hiroyuki Nabae, Vito Cacucciolo, Naoki Hosoya, Yasuaki Kakehi, Shingo Maeda   +13 more
wiley   +1 more source

Bioinspired Mechanisms and Actuation of Soft Robotic Crawlers

Advanced Science, EarlyView.
Researchers have been developing soft materials and robotic crawlers inspired by soft‐bodied animals to mimic effective crawling in complex environments. This review explores the state‐of‐the‐art in soft crawlers, highlighting the interaction between materials, crawling mechanisms, actuation, and applications. The review concludes by providing insights
Min Pan, Miaomiao Liu, Jiayi Lei, Yunyi Wang, Changhong Linghu, Chris Bowen, K. Jimmy Hsia   +6 more
wiley   +1 more source

Vitrification of Heart Valve Tissues

, 2014
Application of the original vitrification protocol used for pieces of heart valves to intact heart valves has evolved over time. Ice-free cryopreservation by Protocol 1 using VS55 is limited to small samples where relatively rapid cooling and warming rates are possible.
Lia H. Campbell, Elizabeth D. Greene, Kelvin G. M. Brockbank, Kelvin G. M. Brockbank, Zhenzhen Chen   +4 more
openaire   +5 more sources

Fish Swim Bladder‐Derived ECM Hydrogels Effectively Treat Myocardial Ischemic Injury through Immunomodulation and Angiogenesis

Advanced Science, EarlyView.
A unique hydrogel based on extracellular matrix from fish swim bladder, which is suitable for transcatheter delivery and possesses remarkable reparative capabilities for treating heart failure, is developed. It emerges as a multi‐effect factor profoundly influencing inflammation regulation, angiogenesis, and myocardial metabolism.
Yulong Fu, Canran Gao, Hailing Zhang, Jing Liu, Boxuan Li, Wei Chen, Xiuping Chen, Xue Lin, Ligang Fang, Zhihong Wang   +9 more
wiley   +1 more source