Results 21 to 30 of about 2,899,304 (242)

Mechanisms of heart valve development and disease

Development, 2020
The valves of the heart are crucial for ensuring that blood flows in one direction from the heart, through the lungs and back to the rest of the body. Heart valve development is regulated by complex interactions between different cardiac cell types and ...
Anna O’Donnell, K. Yutzey
semanticscholar   +1 more source

Heart valve isogeometric sequentially-coupled FSI analysis with the space–time topology change method

Computational Mechanics, 2020
Heart valve fluid–structure interaction (FSI) analysis is one of the computationally challenging cases in cardiovascular fluid mechanics. The challenges include unsteady flow through a complex geometry, solid surfaces with large motion, and contact ...
Takuya Terahara, K. Takizawa, T. Tezduyar, Y. Bazilevs, M. Hsu   +4 more
semanticscholar   +1 more source

Biology and Biomechanics of the Heart Valve Extracellular Matrix

Journal of Cardiovascular Development and Disease, 2020
Heart valves are dynamic structures that, in the average human, open and close over 100,000 times per day, and 3 × 109 times per lifetime to maintain unidirectional blood flow.
Karthik M. Kodigepalli, Kaitlyn Thatcher, Toni M West, D. Howsmon, F. Schoen, M. Sacks, C. Breuer, J. Lincoln   +7 more
semanticscholar   +1 more source

Macrophage lineages in heart valve development and disease.

Cardiovascular Research, 2020
Heterogeneous macrophage lineages are present in the aortic and mitral valves of the heart during development and disease. These populations include resident macrophages of embryonic origins and recruited monocyte-derived macrophages prevalent in disease.
A. J. Kim, Na Xu, K. Yutzey
semanticscholar   +1 more source

Reversing Blood Flows Act through klf2a to Ensure Normal Valvulogenesis in the Developing Heart [PDF]

, 2009
Heart valve anomalies are some of the most common congenital heart defects, yet neither the genetic nor the epigenetic forces guiding heart valve development are well understood.
A. C Oates, A. F Hurlstone, A. F Moorman, A. G Passerini, A. M Malek, A. R Brooks, A. S Forouhar, Arian S. Forouhar, B. C Groenendijk, B. C Groenendijk, C Ethier, C Hahn, C. H Kim, D Beis, D. J Milan, David Wu, Diane Plummer, E Berdougo, E. C Walsh, E. J Armstrong, G Bendig, G Garcia-Cardena, G. B Atkins, G. P Sorescu, H Kokubo, H. J Auman, Hiroshi Hamada, J Alexander, J Pan, J. L Galloway, J. N Chen, J. R Hove, J. S Lee, Julien Vermot, K. M Parmar, L. A Timmerman, M Liebling, M Xin, M Yamada, Michael Liebling, Morteza Gharib, N Sultana, N. C Chi, N. C Chi, P. J Scherz, R. D Kortschak, R. J Dekker, R. J Dekker, S Isogai, S Quintin, S. M McCormick, S. M Meadows, S. W Jin, Scott E. Fraser, T Bartman, T Bartman, T Lecuit, T Lecuit, T. R Cummins, X. L Wang, Y Fung   +60 more
core   +5 more sources

A geometrically adaptable heart valve replacement

Science Translational Medicine, 2020
A biomimetic prosthetic heart valve is geometrically adaptable to accommodate somatic growth and structural asymmetries within the hearts of sheep.
Sophie C. Hofferberth, M. Saeed, L. Tomholt, Matheus C. Fernandes, C. Payne, K. Price, G. Marx, J. Esch, David W Brown, Jonathan Brown, P. Hammer, R. Bianco, J. Weaver, E. Edelman, P. D. del Nido   +14 more
semanticscholar   +1 more source

Dynamic Views of Structure and Function during Heart Morphogenesis [PDF]

, 2006
Congenital heart defects remain the most common birth defect in humans, occurring in over 1% of live births. The high prevalence of cardiac malformations can be partially attributed to limited knowledge regarding the embryonic roots of the disease.
Forouhar, Arian Soroush
core   +1 more source

Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials [PDF]

, 2015
Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very ...
Gerosa, Gino, Iop, Laura
core   +4 more sources

Nanopatterned acellular valve conduits drive the commitment of blood-derived multipotent cells [PDF]

, 2016
Considerable progress has been made in recent years toward elucidating the correlation among nanoscale topography, mechanical properties, and biological behavior of cardiac valve substitutes.
Aguiari, Paola, Barbon, Silvia, Bertalot, Thomas, Conconi, MARIA TERESA, DI LIDDO, Rosa, Gandaglia, Alessandro, Gerosa, Gino, Iop, Laura, Mandoli, Amit, Parnigotto, PIER PAOLO, Schrenk, Sandra, Tasso, Alessia   +11 more
core   +2 more sources

Transcatheter Mitral‐Valve Repair in Patients with Heart Failure

New England Journal of Medicine, 2018
BACKGROUND Among patients with heart failure who have mitral regurgitation due to left ventricular dysfunction, the prognosis is poor. Transcatheter mitral‐valve repair may improve their clinical outcomes.
G. Stone, J. Lindenfeld, W. Abraham, S. Kar, Scott Lim, Jacob M. Mishell, B. Whisenant, P. Grayburn, M. Rinaldi, S. Kapadia, V. Rajagopal, I. Sarembock, A. Brieke, S. Marx, D. Cohen, N. Weissman, M. Mack   +16 more
semanticscholar   +1 more source