Results 201 to 210 of about 209,630 (306)

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Reduced order computational fluid dynamic simulations in the thoracic aorta are associated with disease recorded in a medical biobank. [PDF]

Sci Rep
Sokolow R, Bhattacharya A, Kissas G, Thompson EW, Beeche C, Swago S, Zhang D, Viswanadha M, Morse C, Chirinos J, Damrauer S, Verma A, Perdikaris P, Rader DJ, Witschey WR, Penn Medicine Biobank.   +15 more
europepmc   +1 more source

Lineage labeling with zebrafish hand2 Cre and CreERT2 recombinase CRISPR knock‐ins

Developmental Dynamics, EarlyView.
Abstract Background The ability to generate endogenous Cre recombinase drivers using CRISPR‐Cas9 knock‐in technology allows lineage tracing, cell type‐specific gene studies, and in vivo validation of inferred developmental trajectories from phenotypic and gene expression analyses. This report describes endogenous zebrafish hand2 Cre and CreERT2 drivers
Zhitao Ming, Fang Liu, Hannah R. Moran, Robert L. Lalonde, Megan Adams, Nicole K. Restrepo, Parnal Joshi, Stephen C. Ekker, Karl J. Clark, Iddo Friedberg, Saulius Sumanas, Chunyue Yin, Christian Mosimann, Jeffrey J. Essner, Maura McGrail   +14 more
wiley   +1 more source

Dynamic improvement of tricuspid valve leaflets coaptation and tricuspid regurgitation without surgical treatment: a case report. [PDF]

Eur Heart J Case Rep
Minami H, Yoshida A, Onishi K, Fujita K, Nakazawa G.   +4 more
europepmc   +1 more source

Under pressure: The first valve-in-valve transcatheter aortic valve implantation for stenosis of a BioValsalva prosthesis using a Sapien 3 Ultra balloon expandable valve in a patient with complex congenital heart disease

, 2022
Clare Rayner, Amanda Sherwen, Umair Hayat, Heath Adams   +3 more
openalex   +1 more source

Association of COPD with adverse outcomes in heart failure patients with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 2, Page 799-808, April 2025.
Abstract We performed a systematic review and meta‐analysis to detect the impact of chronic obstructive pulmonary disease (COPD) on the prognosis of heart failure patients with preserved ejection fraction (HFpEF). We systematically screened eligible literature from three electronic databases, PubMed, EMBASE and Cochrane Library, up to April 2023.
Shuo Xu, Zhenbang Gu, Wengen Zhu, Shenghui Feng   +3 more
wiley   +1 more source

A case of aortic abscess and acute kidney injury caused by chronic Q fever. [PDF]

BMC Infect Dis
Liao Z, Zhen H, Zhang R, Pai P, Lu Y, Li X, Cui L, Wang G, He H, Xiang C, Zhang L.   +10 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Incident heart failure: comparing management and outcome in primary and hospital settings in Western Sweden 2008–2017

ESC Heart Failure, Volume 12, Issue 2, Page 832-838, April 2025.
Abstract Aim Heart failure (HF) is a highly prevalent condition managed in both primary care (PC) and hospital care (HC)‐based settings. HF patients managed in these two settings may differ in their demography, comorbidities and outcomes, so we aimed to compare the patient management in PC and HC in the Västra Götaland Region (VGR) in Sweden.
Xiaojing Chen, Aldina Pivodic, Maria Schaufelberger, Annika Rosengren, Michael Fu   +4 more
wiley   +1 more source

Aortic Regurgitation in a Patient with Rheumatoid Arthritis/Systemic Lupus Erythematosus Overlap Syndrome (Rhupus): Case Report and Review of Literature. [PDF]

J Cardiovasc Dev Dis
Radić M, Đogaš H, Bečić T, Šimac P, Jukić I, Radić J, Fabijanić D.   +6 more
europepmc   +1 more source