Biomolecules & BiomedicineHeart valve diseases are a prevalent cardiovascular pathology worldwide, affecting nearly 2.5% of the population. Degenerative aortic stenosis is the most common form of heart valve disease.
Igor Mokryk +5 more
doaj +1 more source
Altered Hemodynamics in the Embryonic Heart Affects Outflow Valve Development
Journal of Cardiovascular Development and Disease, 2015 Cardiac valve structure and function are primarily determined during early development. Consequently, abnormally-formed heart valves are the most common type of congenital heart defects.
Vinal Menon +3 more
doaj +1 more source
Transcatheter pulmonary valve replacement in congenital heart diseases
Pediatric Investigation, 2022 Surgical repair of a variety of congenital heart diseases involves repair of the right ventricular outflow tract (RVOT) with valved or non‐valved conduit to connect the right ventricle (RV) to the pulmonary artery (PA) or just patch enlargement of the ...
Adolphus Kai‐Tung Chau
doaj +1 more source
A new technological system to revolutionize the management of valvular heart diseases: transcatheter aortic valve for the treatment of aortic stenosis [PDF]
arXiv, 2019 The goal of this study is a technology analysis of a revolution for the management of valvular heart diseases given by new technological system based on transcatheter artificial aortic valve, a delivery catheter and a loading system for the treatment of aortic stenosis (a narrowing of the aortic valve because of calcium build up that restricts blood ...
arxiv
Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors
Toxicologic pathology (Print), 2011 Aberrant signaling by transforming growth factor-β (TGF-β) and its type I (ALK5) receptor has been implicated in a number of human diseases and this pathway is considered a potential target for therapeutic intervention.
M. Anderton +8 more
semanticscholar +1 more source
Epidemiology of valvular heart disease in a Swedish nationwide hospital-based register study
Heart, 2017 Objective Transitions in the spectrum of valvular heart diseases (VHDs) in developed countries over the 20th century have been reported from clinical case series, but large, contemporary population-based studies are lacking.
P. Andell +7 more
semanticscholar +1 more source
Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis
International Journal of Molecular Sciences, 2018 Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing prevalence in western societies. Statins are widely applied in atherosclerosis therapy, whereas no pharmacological interventions are available for the treatment of ...
A. Reustle, M. Torzewski
semanticscholar +1 more source
A hybrid echocardiography-computational fluid dynamics framework for ventricular flow simulations [PDF]
, 2019 Image-based computational fluid dynamics (CFD) has emerged as a powerful tool to study cardiovascular flows while 2D echocardiography (echo) is the most widely used non-invasive imaging modality for diagnosis of heart disease. Here, echo is combined with CFD, i.e., an echo-CFD framework, to study ventricular flows.
arxiv +1 more source
Editorial: Heart valve diseases: from molecular mechanisms to clinical implications. [PDF]
Front Mol Med, 2023 Ibarrola J, Lopez-Andres N.
europepmc +1 more source
A coupled mitral valve -- left ventricle model with fluid-structure interaction [PDF]
arXiv, 2017 Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. With advancements in cardiac imaging, nonlinear mechanics and computational techniques, it is now possible to explore the mechanics of valve-heart interactions using anatomically and physiologically realistic ...
arxiv