Results 291 to 300 of about 133,938 (359)

Population pharmacokinetics of TBAJ‐587 and its main metabolites—Evaluation of different loading dose strategies and early dose selection

British Journal of Clinical Pharmacology, EarlyView.
Background and Aim The rise of drug‐resistant tuberculosis (TB) poses a need for new drugs and combinations. TBAJ‐587, a new diarylquinoline (DARQ), has shown promising efficacy in preclinical studies. This work aimed to describe the pharmacokinetics (PK) of TBAJ‐587 and its metabolites M2 and M3 after single ascending dosing in healthy volunteers and ...
Albin A. M. Leding, Paul Bruinenberg, Almari Conradie, Jerry Nedelman, Antonio Lombardi, Dean Hickman, Ulrika S. H. Simonsson   +6 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Kdm7aa Orchestrates an Immunomodulatory Cardiomyocyte Program to Enable Zebrafish Heart Regeneration. [PDF]

Int J Mol Sci
Lin W, Shi Y, Tian J, Liu X, Weng F, Wu Z.   +5 more
europepmc   +1 more source

Trandolapril Attenuates Pro-Arrhythmic Downregulation of Cx43 and Cx40 in Atria of Volume Overloaded Hypertensive and Normotensive Rats. [PDF]

Biomolecules
Sýkora M, Ondreják Andelová K, Mrvová A, Szeiffová Bačová B, Tribulová N.   +4 more
europepmc   +1 more source

Topography of the Papillary Muscles in the Mitral Valve Complex and Their Relevance for Mitral Valve Function. [PDF]

J Cardiovasc Dev Dis
Van Laethem AJ, Figiel J, Mahnken AH, Ramzan R, Irqsusi M, Vogt S, Rastan AJ.   +6 more
europepmc   +1 more source

Myocardial ischemia after arterial switching operation in transposition of great arteries associated with the upstairs-downstairs relationship of the ventricles and abnormal coronary distribution. [PDF]

J Cardiol Cases
Yonehara K, Takigiku K, Akazawa Y, Konuma T.   +3 more
europepmc   +1 more source

In Silico Optimisation of Regenerative Cell Therapy in the Infarcted Human Ventricles to Mitigate Arrhythmic Burden

Riebel LL, Wang ZJ, Zhou X, Arantes Berg L, Trovato C, Rodriguez B.   +5 more
europepmc   +1 more source

The livebearers platyfish and swordtails partially regenerate their hearts with persistent scarring

Hisler V, Rees L, Blanchoud S, Lischer HE, Bruggmann R, Jaźwińska A.   +5 more
europepmc   +1 more source