Results 91 to 100 of about 60,130 (290)
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Type I interferons modulate autophagy to shape gemcitabine response in pancreatic cancer cells
FEBS Open Bio, EarlyView.Type I interferons differentially modulate autophagy and the response of pancreatic cancer cells to gemcitabine. IFNα2b stimulates autophagic flux and protects cells from gemcitabine‐induced cell death, contributing to chemoresistance. In contrast, IFNβ1a inhibits autophagosome formation and enhances gemcitabine‐induced cell death, resulting in ...
Lucy E. Bonilla +10 more
wiley +1 more source
, 2015 A story about hearing a fragment of a song (Childish Gambino's Heartbeat) and later rediscovering it in more detail, analyzing it as a rap song and relating to it ...
Kumar, Priyanka
core +1 more source
International Journal of Information and Communication Technology Research, 2020 Reliable detection of life under rubble and collapsed buildings after disasters like earthquake or air raid is the most important issue in life-detection process.
Kamyar Abyar +3 more
doaj
FEBS Open Bio, EarlyView.Functional screening identified PcSyn14890, a cyanobacteria‐specific protein that enhances growth and stress resistance in E. coli and Synechocystis PCC6803. Although we expected it to function as a molecular chaperone, it was unable to protect against thermal aggregation of GAPDH.
Akiyo Yamada +7 more
wiley +1 more source
Mokslas: Lietuvos Ateitis, 2015 This paper proposes an algorithm to reduce the noise distortion influence in heartbeat annotation detection in electrocardiogram (ECG) signals. Boundary estimation module is based on energy detector.
Andrius Gudiškis
doaj +1 more source
KIC 3749404: a heartbeat star with rapid apsidal advance indicative of a tertiary component [PDF]
, 2016 Heartbeat stars are eccentric (e> 0.2) ellipsoidal variables whose light curves resemble a cardiogram. We present the observations and corresponding model of KIC 3749404, a highly eccentric (e = 0.66), short period (P = 20.3 d) heartbeat star with ...
Kurtz, D. W. +9 more
core +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source