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The infusion of menthol into the esophagus evokes cold sensations in healthy subjects but induces heartburn in patients with gastroesophageal reflux disease (GERD).

Diseases of the esophagus, 2019
Recent studies in animal models have reported that some afferent fibers innervating the esophagus express the cold receptor TRPM8. In the somatosensory system the stimulation of TRPM8 leads to cold sensations and in certain circumstances alleviates pain.
P. Bánovčin   +5 more
semanticscholar   +1 more source

Heartburn

Nutrition Today, 2018
Heartburn (pyrosis) can be defined as a burning sensation behind the sternum. Heartburn is typically caused by stomach acid that has refluxed back into the esophagus through the lower esophageal sphincter (which is normally closed except when swallowing). Most people who experience heartburn actually produce normal amounts of stomach acid, so heartburn
openaire   +2 more sources

Mechanisms of heartburn

Nature Clinical Practice Gastroenterology & Hepatology, 2008
Heartburn is a typical symptom of GERD. The spectrum of diseases associated with GERD includes reflux esophagitis, Barrett's esophagus and nonerosive reflux disease (NERD). Although acid reflux is the classic cause of heartburn in patients with erosive esophagitis, the relationship between acid and heartburn is far from clear, especially in patients ...
Daphne, Ang, Daniel, Sifrim, Jan, Tack
openaire   +2 more sources

Stress and heartburn

Journal of Psychosomatic Research, 2005
The majority of heartburn sufferers believe that stress exacerbates their heartburn [1]. This perception is supported by a recent study that documented that the presence of a severe sustained life stress in the previous 6 months predicted increased heartburn in the succeeding months [2].
openaire   +2 more sources

Heartburn: Community perceptions

Journal of Gastroenterology and Hepatology, 2000
Abstract Background and Aims : To determine the prevalence of heartburn in the Australian community, and document factors precipitating it and medications used in treatment. Methods : Telephone interviews with 1200 individuals aged 18 years or more were conducted one weekend in 1996.
T D, Bolin   +3 more
openaire   +2 more sources

Diet and Heartburn

JAMA: The Journal of the American Medical Association, 1979
SYMPTOMATIC gastroesophageal reflux (heartburn) is a ubiquitous postprandial complaint. Although usually a recurring complaint, it can be transient (as in the third trimester of pregnancy) or persistent and progressive (as in progressive systemic sclerosis).
B, Chernow, D O, Castell
openaire   +2 more sources

Heartburn in pregnancy

The American Journal of Digestive Diseases, 1962
Half of pregnant women have heartburn during pregnancy. Most primaparas and some multiparas are spontaneously relieved in the last weeks as the uterus descends, but all are invariably relieved immediately after delivery. The heartburn is a newly experienced burning sensation of variable severity in the throat or substernal region, frequently radiating ...
R, NAGLER, H M, SPIRO
openaire   +2 more sources

Determinants of pregnancy heartburn

BJOG: An International Journal of Obstetrics & Gynaecology, 1992
ABSTRACTObjective To study the prevalence and severity of reflux symptoms in pregnancy.Design Self‐administered questionnaire detailing age, race, gestational age, parity, weight, height, symptoms and severity of gastro‐oesophageal reflux.Setting An antenatal clinic in a teaching hospital.Subjects 607 consecutive women at ...
J M, Marrero   +4 more
openaire   +2 more sources

Heartburn

JAMA, 1976
There is currently controversy as to the importance of the radiologic demonstration of a hiatal hernia, reflux, or both as the explanation of heartburn. It is clear, however, that clinical-radiologic correlation requires additional observations such as the straightness of the potential path for reflux, the presence of a contractile esophagogastric ...
openaire   +2 more sources

Heartburn

Chest, 2005
William A. Sodeman, Thomas C. Sodeman
openaire   +2 more sources

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