Results 81 to 90 of about 3,219,487 (379)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Modelling linered engine blocks [PDF]

open access: yes, 1991
Factors that affect heat transfer in the linered aluminium engine block are examined to determine their importance. Conduction is found to be the dominant mode of heat transfer, and the interface is characterised as imperfect contact if there are no ...
Ha, J.
core  

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

open access: yesFEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh   +7 more
wiley   +1 more source

Natural Convection Heat Transfer from an Isothermal Plate

open access: yesThermo, 2023
Using boundary-layer theory, natural convection heat transfer formulas that are accurate over a wide range of Rayleigh numbers (Ra) were developed in the 1970s and 1980s for vertical and downward-facing plates.
Aubrey Jaffer
doaj   +1 more source

Efficiency at maximum power of a laser quantum heat engine enhanced by noise-induced coherence. [PDF]

open access: yesPhysical Review E, 2018
Quantum coherence has been demonstrated in various systems including organic solar cells and solid state devices. In this article, we report the lower and upper bounds for the performance of quantum heat engines determined by the efficiency at maximum ...
K. Dorfman, Dazhi Xu, Jianshu Cao
semanticscholar   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

open access: yesFEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu   +6 more
wiley   +1 more source

Start up system for hydrogen generator used with an internal combustion engine [PDF]

open access: yes, 1977
A hydrogen generator provides hydrogen rich product gases which are mixed with the fuel being supplied to an internal combustion engine for the purpose of enabling a very lean mixture of that fuel to be used, whereby nitrous oxides emitted by the engine ...
Cerini, D. J., Houseman, J.
core   +1 more source

The Thermodynamic Efficiency in Static and Dynamic Black Holes

open access: yes, 2017
We note that, in extended phase space the cosmological constant is a thermodynamic variable. In this paper, this cosmological constant lead us to consider a black hole as a heat engine.
Jafarzade, Kh., Sadeghi, J.
core   +1 more source

Algorithmic quantum heat engines [PDF]

open access: yesPhysical Review E, 2019
We suggest alternative quantum Otto engines, using heat bath algorithmic cooling with a partner pairing algorithm instead of isochoric cooling and using quantum swap operations instead of quantum adiabatic processes. Liquid state nuclear magnetic resonance systems in a single entropy sink are treated as working fluids.
Emre Köse   +4 more
openaire   +4 more sources

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

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