Results 221 to 230 of about 1,595,198 (282)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

No evidence of higher peak heat tolerance in the afternoon or with opportunity for thermal behaviour during low-intensity work in uncompensable heat. [PDF]

Exp Physiol
Stothers T, Gibbons TD, Thomas KN, Jones E, Campbell HA, Cotter JD.   +5 more
europepmc   +1 more source

Dual‐targeted nanomedicine delivering doxorubicin and nitric oxide for tumor immunomodulation and synergistic therapy

BMEMat, EarlyView.
The mechanism of HA‐DS@PLGA nanoparticles co‐delivering DOX and SNAP (an NO donor) to suppress tumor growth, remodel the tumor microenvironment, and enhance antitumor immune responses for effective combinatorial cancer therapy. Abstract Cancer therapeutic efficacy is significantly influenced by tumor immunosuppressive environment possibly induced by ...
Xingzhou Peng, Wei Chen, Shuyu Li, Xiaomin Ma, Yanfeng Dai, Yan Wang, Changqiang Xie, Yazhe Xiao, Hesong Han, Yumiao Zhang, Junjie Wang   +10 more
wiley   +1 more source

Papillary Thyroid Carcinoma with Terminal Immune Exhaustion Phenotype Correlates with Increased Risk of Lymph Node Metastasis: An Exploratory Study Combining Flow Cytometry and TCGA. [PDF]

Cancers (Basel)
Wang S, Cai H, Zhang R, Chen K, Liu W, Huang Z, Yan D, Qu C, Li Z.   +8 more
europepmc   +1 more source

Oral Fluids and Electrolytes in Non-diarrheal Diseases: A Cross-Sectional Study Assessing the Knowledge, Attitude, and Practices of Indian General Physicians. [PDF]

Cureus
Kalra S, Patil C, Patil A, Malve H, Bangale N.   +4 more
europepmc   +1 more source

Disease Burden and Pattern of Healthcare Utilization Among Pilgrims During Hajj 2024: A Cross‑Sectional Analysis. [PDF]

Ann Glob Health
Alharbi KK, Alfaifi MS, Alzahrani AM, Alkathiri AS, Sinky TH.   +4 more
europepmc   +1 more source

Acute Heat Exposure-Related Illness: A Unified Emergency Medicine Framework for Hot Baths, Hot Springs, and Saunas-A Narrative Review. [PDF]

J Clin Med
Yokoyama R, Yarimizu K, Hayasaka T, Sakaguchi K, Kuroki M, Soekawa K, Kobayashi T, Konta T.   +7 more
europepmc   +1 more source

Regional Variations in Characteristics and Statistics of Heat-related Illnesses in the Chungcheong Region (2025). [PDF]

Public Health Wkly Rep
Ahn H, Pyun H, Hwang JY, Choi YH.
europepmc   +1 more source

Heat exhaustion

, 2018
Heat exhaustion is part of a spectrum of heat-related illnesses that can affect all individuals, although children, older adults, and those with chronic disease are particularly vulnerable due to their impaired ability to dissipate heat. If left uninterrupted, there can be progression of symptoms to heatstroke, a life-threatening emergency.
Glen P, Kenny, Thad E, Wilson, Andreas D, Flouris, Naoto, Fujii   +3 more
openaire   +3 more sources