Results 171 to 180 of about 2,478,184 (273)

NS1‐Induced PARP1 Phase Transitions Prolongs Host Transcriptional Pausing to Promote Influenza A Virus Replication

open access: yesAdvanced Science, EarlyView.
After IAV infection, NS1 induces PARP1 phase transition, reducing molecular mobility in condensates, prolonging host transcriptional pause, aiding RdRp cap snatching, and promoting viral transcription. ABSTRACT Influenza A virus (IAV) commandeers host transcriptional machinery to replicate, but mechanisms remain elusive.
Shufeng Ma   +12 more
wiley   +1 more source

Genomics highlight an underestimation of phenology sensitivity to the urban heat island effect. [PDF]

open access: yesProc Natl Acad Sci U S A
Blumstein M   +5 more
europepmc   +1 more source

High‐Brightness and Ultra‐Long‐Lifetime Spin Quantum Dot Light‐Emitting Diodes Enabled by Efficient Injection of Spin‐Polarized Holes Through a Hybrid Hole Transport Layer

open access: yesAdvanced Science, EarlyView.
This work employs a hybrid hole transport layer to enhance hole transport efficiency, resulting in improved performance for the final device. It achieves an external quantum efficiency of 6.68%, a circularly polarized electroluminescence asymmetry factor of 0.026, and a high luminance of 14,370 cd/cm2, representing the highest luminance reported to ...
Fengqi Qiu   +8 more
wiley   +1 more source

Conjugated Polymer‐Microbe Interactions Trigger Regulatory Reprogramming for Enhanced Bioelectrocatalysis

open access: yesAdvanced Science, EarlyView.
Conjugated polymer‐supported bioelectrochemical systems are shown to enhance microbial electrosynthesis by triggering coordinated electrochemical, transcriptional, post‐transcriptional (sRNA), metabolic, and protein‐level responses. Integrated multi‐omics and electrochemical analyses reveal selective physiological remodeling associated with improved ...
David Ohayon   +8 more
wiley   +1 more source

Acoustically Activatable Drug‐Loaded Nanodroplets for Mechanochemical Therapy in Solid Tumors

open access: yesAdvanced Science, EarlyView.
Microfluidically fabricated drug‐loaded nanodroplets are sequentially activated by dual‐frequency ultrasound through acoustic droplet vaporization followed by bubble collapse, enabling spatially controlled drug release and mechanical tumor fractionation, resulting in synergistic mechanochemotherapy and prolonged survival.
Tiran Bercovici   +4 more
wiley   +1 more source

Sarbecoviruses Suppress Innate Immunity by Recruiting PPM1A to Modulate STAT2 and ORF9b Phosphorylation

open access: yesAdvanced Science, EarlyView.
Sarbecovirus ORF9b recruits host phosphatase PPM1A to suppress innate immunity through dual mechanisms. PPM1A directly dephosphorylates ORF9b to sustain its activity and indirectly downregulates STAT2 phosphorylation to impair interferon signaling. Pharmacological inhibition of PPM1A restores antiviral responses and limits sarbecovirus replication ...
Lixiang Xie   +24 more
wiley   +1 more source

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