Results 61 to 70 of about 3,627,148 (255)
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Two-dimensional radiometric map of environmental radiation levels in a nuclear medicine service
Brazilian Journal of Radiation SciencesNuclear Medicine in Brazil has shown significant growth, with approximately 2 million procedures performed annually across 436 facilities. Ensuring that radiation exposure remains within safe limits is critical to protect patients and staff, making ...
Maria Eduarda santos +2 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Mapping Community Determinants of Heat Vulnerability
Environmental Health Perspectives, 2009 The evidence that heat waves can result in both increased deaths and illness is substantial, and concern over this issue is rising because of climate change. Adverse health impacts from heat waves can be avoided, and epidemiologic studies have identified specific population and community characteristics that mark vulnerability to heat waves.We situated
Reid, Colleen E. +6 more
openaire +4 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
The harmonic map heat flow from surfaces [PDF]
We present a study of the harmonic map heat flow of Eells and Sampson in the case that the domain manifold is a surface. Particular emphasis has been placed on the singularities which may occur, as described by Struwe, and the analysis of the flow ...
Topping, Peter
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Determination of Drought and Wet Periods of the Black Sea Region Using SPI Method
Doğal Afetler ve Çevre DergisiThe Black Sea region is the region with the highest rainfall in Türkiye. However, precipitation in the Black Sea region varies considerably both between years and within the region.
Yasemin Deniz Öztürk, Ramazan Ünlü
doaj +1 more source
Frontiers in Genetics, 2020 We untangled key regions of the genetic architecture of grain yield (GY) in CIMMYT spring bread wheat by conducting a haplotype-based, genome-wide association study (GWAS), together with an investigation of epistatic interactions using seven large sets ...
Deepmala Sehgal +9 more
doaj +1 more source