Results 51 to 60 of about 278,375 (304)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

The residential heat pumps’ impact on national CO2 emission

open access: yesE3S Web of Conferences, 2018
The decarbonisation potential of residential heat pump technology strongly depends on the public electricity and heat production system. The study presents the national scenarios of replacing the individual heat sources with electrically driven heat ...
Niemierka Elżbieta
doaj   +1 more source

Linear programming control of a group of heat pumps [PDF]

open access: yes, 2015
For a new district in the Dutch city Meppel, a hybrid energy concept is developed based on bio-gas co-generation. The generated electricity is used to power domestic heat pumps which supply thermal energy for domestic hot water and space heating demand ...
Fink, Jiří   +3 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

A Simulation-Optimisation Method for Targeting the Optimal Placement of Heat Pumps in Heat Exchanger Networks

open access: yesChemical Engineering Transactions, 2019
Heat pumps can enhance the utilization of low-grade thermal energy. Setting heat pumps correctly in a heat exchanger network can reduce the consumption of cold and hot utilities, achieving energy saving and pollution reduction.
Ting Li, Minbo Yang, Xiao Feng
doaj   +1 more source

YIMBY Generation – yes in my back yard! UK householders pioneering microgeneration heat [PDF]

open access: yes, 2008
This report summarises the responses to a survey of over 900 households (the largest such UK study to date) who were considering or buying microgeneration heat technologies.
Abelman, Jennie   +2 more
core  

Heat pumps in subarctic areas: current status and benefits of use in Iceland [PDF]

open access: yes, 2017
Heat pumps use the temperature difference between inside and outside areas to modify a refrigerant, either for heating or cooling. Doing so can lower the need for external heating energy for a household to some extent.
Atlason, Reynir Smari   +2 more
core   +3 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov   +3 more
wiley   +1 more source

A Technological Update on Heat Pumps for Industrial Applications

open access: yesEnergies
It is now widely confirmed by scientific evidence that greenhouse gas emissions must be reduced to counteract the effects of global warming. The production of heat for industrial purposes is responsible for 36.8% of world energy-related emissions due to ...
Sergio Bobbo   +4 more
doaj   +1 more source

Heat-pump performance: voltage dip/sag, under-voltage and over-voltage

open access: yesThe Journal of Engineering, 2014
Reverse cycle air-source heat-pumps are an increasingly significant load in New Zealand and in many other countries. This has raised concern over the impact wide-spread use of heat-pumps may have on the grid. The characteristics of the loads connected to
William J.B. Heffernan   +2 more
doaj   +1 more source

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