Results 91 to 100 of about 173,029 (259)

Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]

open access: yes, 1991
Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Soll, Jürgen, Waegemann, Karin
core   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Convective heat transfer and pumping power requirement using nanofluid for the flow through corrugated channel

open access: yes, 2015
Convective heat transfer rate for turbulent flow using nanofluid through both plain and corrugated channel has been investigated numerically in the present study.
Islam, A. K. M. Sadrul   +7 more
core   +1 more source

Research on Heat Pipe Radiator of CRH2 EMUs CI

open access: yes机车电传动, 2012
Development process, product performance, features and application prospects of the heat pipe radiator for CRH2 EMUs’ CI were describled. With comparison to H1X3206, domestic heat pipe radiator DG7027 has achieved and exceeded the requirement value of ...
LI Chun-yang, XIAO Ning, YANG Hong-sheng
doaj  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Nanofluids for heat exchanger improvement: a numerical approach

open access: yes, 2012
Mestrado em Engenharia MecânicaNo panorama industrial, as últimas décadas ficaram marcadas pelo aparecimento do conceito de sustentabilidade, consequência da crescente escassez de recursos e o desaparecimento de ecossistemas.
Freitas, Sylvio Michael Olim de
core  

Absorbed Heat-flux Method for Ground Simulation of On-orbit Thermal Environment of Satellite [PDF]

open access: yesJournal of Astronomy and Space Sciences, 1999
An absorbed heat-flux method for ground simulation of on-orbit thermal environment of satellite is addressed in this paper. For satellite ground test, high vacuum and extremely low temperature of deep space are achieved by space simulation chamber, while
Jeong-Soo Kim, Young-Keun Chang
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Development of Monitoring Control and Fuzzy Control Test of Finned-Tube Heat-Exchanger Test-Board [PDF]

open access: yes, 2006
In order to satisfy the testing requirement of finned-tube heat-exchanger test-board, this paper designs an exclusive auto-monitor and control subsystem, studies the fuzzy control means for the supply air temperature of the heat-exchanger, and ...
Gao, F., Chen, Y., Zhang, B., Zhang, J.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

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