Results 51 to 60 of about 1,109,653 (313)

Survivin and Aurora Kinase A control cell fate decisions during mitosis

open access: yesMolecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir   +2 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Accurate Calculation of Electromagnetic Torque and Harmonic Characteristics of Hydro Generator Based on Positive and Negative Sequence Decoupling

open access: yesIET Electric Power Applications
Aiming at the technical problems of electromagnetic parameter analysis of large hydro generators, this paper innovatively proposes an electromagnetic torque analysis method based on the characteristics of fundamental electric quantity, with the core idea
Peng Hou, Guoguang Zhang, Baojun Ge
doaj   +1 more source

Effect of natural convection on heat storage performance of tubular phase change heat accumulator

open access: yesJournal of Hebei University of Science and Technology, 2023
Aiming at the uncertaity of heat storage efficiency during the melting process of phase-change materials in the heat accumulator and the natural convection heat transfer process in the phase-change region, the influence of natural convection caused by ...
Jingzhi JIANG   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Comparison of CFETR nuclear fusion power plant thermal storage technology

open access: yesHe jishu
BackgroundDue to its pollution-free nature and non consumption of fossil fuels, nuclear fusion is the most ideal future energy source. China is preparing to build a China Fusion Engineering Test Reactor (CFETR) with independent intellectual property ...
LUO Haodong   +5 more
doaj   +1 more source

The role of thermal energy storage in industrial energy conservation [PDF]

open access: yes, 1979
Thermal Energy Storage for Industrial Applications is a major thrust of the Department of Energy's Thermal Energy Storage Program. Utilizing Thermal Energy Storage (TES) with process or reject heat recovery systems is shown to be extremely beneficial ...
Duscha, R. A., Masica, W. J.
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Improving the Thermochemical Heat Storage Performance of Calcium Hydroxide in a Fixed-Bed Reactor by Y-Shaped Fins

open access: yesBuildings
Thermochemical heat storage technology has great development prospects due to its high energy storage density and stable long-term storage capacity.
Guangyao Zhao   +7 more
doaj   +1 more source

Analisis Rugi-Rugi Panas pada Tangki Penyimpan Panas dalam Sistem Pembangkit Listrik Tenaga Matahari

open access: yesJournal of Mechatronics, Electrical Power, and Vehicular Technology, 2012
Analysis of heat loss on heat storage tank in solar power generation system is intended to determine the heat loss value during storage. Selection of insulation material, insulation thickness, time of storage and heat storage fluid affects the heat ...
Ghalya Pikra   +3 more
doaj   +1 more source

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