Results 121 to 130 of about 222,334 (313)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Pilot Plant for Solar Process Steam Supply
, 2008 An aluminium upgrading process will be supplied by steam directly generated in parabolic trough collectors. In this first of it’s kind installation in an industrial environment, steam at 4 bar will be fed into the existing distribution lines of the ...
Walder, Markus +4 more
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
The integration of heat pipe technology into natural ventilation systems [PDF]
, 2013 The aim of this research was to integrate heat pipe technology into natural ventilation air streams to provide passive cooling in regions of hot arid climatic conditions without the use of mechanical assistance.
Chaudhry, Hassam Nasarullah
core
Performance Analysis and Optimal Design of Heat Exchangers and Heat Exchanger Networks
, 2001 This thesis presents a study on performance analysis and optimal design of heat exchangers and heat exchanger networks. The study includes an experimental investigation of steam condensation in plate heat exchangers, optimal design of plate heat ...
Wang, Lieke
core +1 more source
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
, 2012 Aiming at the issue of bio-fouling build-up on heat exchanger\u27s surface in wastewater source heat pump (WWSHP) systems, a novel dry-expansion shell-and-tube wastewater evaporator (DESTE) with defouling function was developed.
Wang, Xinlei +3 more
core +1 more source
High-Temperature Heat Pumps. Task 1 – Technologies.:Task Report
, 2023 This report has been compiled as part of the IEA HPT Annex 58 about High-Temperature Heat Pumps (HTHP). The Annex is structured into the following 5 tasks:-Task 1: Technologies – State of the art and ongoing developments for systems and components-Task 2:
Gachot, Clément +32 more
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source