Results 161 to 170 of about 222,334 (313)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Effect Of Operational Parameters On Heat and Mass Transfer In Generator of R134a/DMF Absorption Refrigeration System

open access: yes, 2012
Vapour absorption refrigeration systems (VARS) has regained the attention due to their potential for renewable/waste heat utilization. To improve the efficiency of these systems, it becomes obligatory to make component level studies on processes. In this
Pasupathy, Balamurugan, Annamalai, Mani
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

open access: yesFEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno   +3 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

open access: yesFEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks   +4 more
wiley   +1 more source

Analysis of the Impact of Decreasing District Heating Supply Temperature on Combined Heat and Power Plant Operation

open access: yes
District heating systems are widely used to supply heat to different groups of heat consumers. These systems offer great opportunities for combined heat and power production. In this paper decreasing district heating supply temperature is analyzed in the
Boloņins, Genādijs   +2 more
core  

Industrial Waste Heat Recovery Using Heat Pipes

open access: yes, 1981
For almost a decade now, heat pipes with secondary finned surfaces have been utilized in counter flow heat exchangers to recover sensible energy from industrial exhaust gases.
Ruch, M. A.
core  

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