Results 61 to 70 of about 12,345,819 (252)
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
DNA ligase LigE increases bacterial transformation with damaged extracellular DNA
FEBS Letters, EarlyView.The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan +4 more
wiley +1 more source
WtE plants with energy recovery as part of Europe’s energy sustainability
Architecture, Civil Engineering, EnvironmentThe relevance of this study is determined by the need to reduce dependence on fossil fuels in order to reduce greenhouse gas emissions and improve long-term performance of municipal energy systems.
Pavliuk Nonna +2 more
doaj +1 more source
Methods of air distant control for cadastral works in an agrocomplex [PDF]
E3S Web of Conferencesconsider the technical-theoretical side of the work of neural networks on examples get acquainted with different methods of landing and understand their features, their possibilities and disadvantages compared to the standard methods of using manned ...
Mamazhonov Abdulaziz +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
On the issue of modernization of steam-gas power units [PDF]
E3S Web of ConferencesCombined cycle power plants are an efficient solution for combined heat and power generation; however, during the summer period, their electrical output decreases due to the high ambient air temperature at the gas turbine compressor inlet.
Beloev Hristo +5 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
COMPARATIVE EFFICIENCY OF HEAT-PUMPS APPLICATION IN LOW TEMPERATURE HEAT SUPPLY SYSTEMS [PDF]
, 2015 The article considers comparative operation-efficiency of the low-temperature heatsupply systems with heat pumping plants (HPP) and with hot-water boilers.
M. N. Chepurnoy, N. V. Resident
core
Energy from Waste: Reuse of Compost Heat as a Source of Renewable Energy [PDF]
, 2010 An in-vessel tunnel composting facility in Scotland was used to investigate the potential for collection and reuse of compost heat as a source of renewable energy.
E. R. Lamont +5 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source