Results 111 to 120 of about 6,852,964 (392)

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

open access: yesFEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee   +3 more
wiley   +1 more source

A Method of Calculating a Time-Varying Volume of Combustion Products in the Cylindrical Chamber

open access: yesМеханика машин, механизмов и материалов, 2008
A method of calculating a volume of combustion products when a flame spreads in the closed cylindrical chamber is developed, assuming that the front is spherical for two positions of an ignition source: at the end (central ignition) and cylindrical (side
M.S. Assad   +2 more
doaj  

Heat transfer in a recirculation zone at steady-state and oscillating conditions - the back facing step test case [PDF]

open access: yes, 2008
Steady state and transient heat transfer is a very important aspect of any combustion process. To properly simulate gas to wall heat transfer in a turbulent flow, an accurate prediction of the flow and the thermal boundary layer is required.
Kok, J.B.W.   +3 more
core   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

open access: yesFEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez   +5 more
wiley   +1 more source

Design and Operating Performance of Mechanical Draft Dry Cooling Tower Pre-cooled with Wet Medium

open access: yesZhongguo dianli
In order to solve the problem of insufficient output of mechanical draft dry cooling tower which can’t meet the cooling demand in summer, a mechanical draft dry cooling tower with wet medium pre-cooling inlet air system is designed in this paper.
Mingwei WANG   +6 more
doaj   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Numerical Modeling of a Flame Surface in the Closed Chamber

open access: yesМеханика машин, механизмов и материалов, 2008
The method for modeling of the flame surface in a closed cylindrical bomb is developed assuming preserving the spherical flame front at interactions with confined walls.
M.S. Assad, V.N. Mironov, O.G. Penyazkov
doaj  

Two-Dimensional Simulation of Mass Transfer in Unitized Regenerative Fuel Cells under Operation Mode Switching

open access: yesEnergies, 2016
A two-dimensional, single-phase, isothermal, multicomponent, transient model is built to investigate the transport phenomena in unitized regenerative fuel cells (URFCs) under the condition of switching from the fuel cell (FC) mode to the water ...
Lulu Wang   +3 more
doaj   +1 more source

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