Results 131 to 140 of about 4,092,332 (300)

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

GBS‐MeDIP: A method for the simultaneous identification of genetic and epigenetic variants in tumors

FEBS Open Bio, EarlyView.
GBS‐MeDIP combines DNA sequencing with enrichment of methylated DNA to profile genetic and epigenetic variation in the same reduced genomic fraction. Applied to gastric cancer and parathyroid tumors, it identifies sequence variants, copy number changes, and differentially methylated regions together, helping distinguish true epigenetic changes from ...
Fábio Pértille, Shiva Rezaei, Julia Uffenorde, Oliver Gimm, Mohammad Ali Hosseinpour Feizi, Luiz Lehmann Coutinho, Carlos Guerrero‐Bosagna   +6 more
wiley   +1 more source

Core plasma fueling by fast inward particle transport after hydrogen pellet injection in Wendelstein 7-X

Nuclear Fusion
A large database of more than 1000 individual cryogenic hydrogen pellets injected into Wendelstein 7-X for plasma fueling was analyzed to improve the understanding of the three phases of the process: the ablation, deposition and transport of the pellet ...
H. Damm, J. Baldzuhn, R.C. Wolf, T.S. Petersen, J. Schilling, N. Panadero, S.A. Bozhenkov, C. Brandt, K.J. Brunner, G. Fuchert, J. Knauer, A. Langenberg, S. Kwak, N.A. Pablant, E. Pasch, H. Thomsen, the W7-X Team   +16 more
doaj   +1 more source

Heat and Mass Transport in Carbon Nantubes

, 2010
We have investigated heat and mass transport in single-walled carbon nanotubes (SWNTs) using molecular dynamics methods. Particular attention was paid on the non-equilibrium dynamics at the interface between SWNT and other materials, which strongly ...
Carlborg, Carl Fredrik,, Maruyama, S., Shiomi, J., Junichiro Shiomi, Shigeo Maruyama, Carl Fredrik Carlborg   +5 more
core   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Scaling of Latitude‐Dependent Heat Transport in Geostrophic Convection

Geophysical Research Letters
Latitudinal variations in heat transport shape the thermal and magnetic evolution of rapidly rotating planets, stars, and icy moons. Although global simulations have revealed strong equatorial–polar contrasts, a predictive scaling theory has been lacking.
Veeraraghavan Kannan, Varghese Mathai, Xiaojue Zhu   +2 more
doaj   +1 more source

Neurochemical Endpoints to Inform Early‐Stage Trials of Spinocerebellar Ataxia 2 and 3 in a Multisite Setting

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Neurochemical levels measured by brain MR spectroscopy (MRS) have been proposed as endpoints for clinical trials in early‐stage spinocerebellar ataxia (SCA) trials. We tested their trial‐readiness by quantifying neurochemicals in three affected brain regions in early‐stage cohorts of SCA2 and SCA3, examining their reproducibility in ...
James M. Joers, Yaqiao Wei, Dinesh K. Deelchand, Adam Berrington, Young Woo Park, Guita Banan, Michal Povazan, Jens T. Rosenberg, André J. W. van der Kouwe, Tetsuo Ashizawa, Khalaf O. Bushara, Chiadi U. Onyike, Sub H. Subramony, Jeremy D. Schmahmann, Brian J. Soher, Peter B. Barker, Thomas H. Mareci, Eva‐Maria Ratai, Lynn E. Eberly, Gülin Öz   +19 more
wiley   +1 more source

Observed Subsurface Marine Heatwaves Driven by Subsurface Eddies in the Western Tropical Pacific Ocean

Geophysical Research Letters
Marine heatwaves (MHWs) are extreme warm water events with high impact, but the drivers of subsurface MHWs, particularly the role of subsurface eddies in the occurrence of subsurface MHWs, are unclear yet. Previous studies suggest that surface warm water
Shihan Li, Shijian Hu, Xiangzhou Song
doaj   +1 more source

Baseline Neuroinflammation Stratifies TSPO‐PET Response to Disease‐Modifying Therapy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate which baseline clinical and imaging characteristics best predict TSPO‐PET‐measurable reduction in glial activation following treatment of multiple sclerosis (MS), to utilize this information for designing more efficient biomarker‐based clinical trials targeting glial activation.
Marlene T. Morch, Markus Matilainen, Giulia N. Baldrighi, Marjo Nylund, Maija Saraste, Laura Airas   +5 more
wiley   +1 more source

Pacific Arctic sea ice loss resulting from atmospheric circulation-driven ocean heat transport

Environmental Research Letters
Arctic sea ice is disappearing rapidly, but the melt comes from two different pathways: direct surface warming and the movement of warm water into the Arctic. This study focuses on the latter, i.e.
Yungi Hong, S-Y Simon Wang, Jin-Ho Yoon
doaj   +1 more source