Results 51 to 60 of about 3,656,746 (202)

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Numerical Simulation of Heat Transport from the Electric Arc Furnace to the Heat Recovery System

, 2016
The paper presents a numerical model of heat transport from melting charge of the electric arc furnace designed for ferroalloy production, into a cooled roof of the electric arc furnace from which waste heat is led to the heating system of a company. The
Stanislav Gavlas, Richard Lenhard, Tadeas Ochodek, Milan Malcho, Jozef Jandacka   +4 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Dynamic heat transport in open quantum systems [PDF]

Heat transport in driven nanoscale systems plays a critical role in quantum technologies and in non-equilibrium thermodynamics. More specifically, the investigation of time-dependent temperatures in quantum systems is a developing field that has seen ...
de Castro Portugal, Pedro Vinicius
core   +1 more source

The Bending of Three-Layer Elastic Core with Variable Stiff Shell

Механика машин, механизмов и материалов, 2008
The bending of three-layer elastic core with variable thickness of one of two stiff shells is considered. To describe kinematics of asymmetrical over thickness pack of the core the hypotheses of the broken normal are accepted.
Yu.M. Pleskachevsky, E.E. Starovoytova
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Airborne lidar observations of water vapour variability and transport [PDF]

, 2012
Water vapour, a minor constituent of the earth’s atmosphere, plays a major role in the radiation budget and the water cycle with important implications for weather and climate. Due to the heterogeneous distribution of its sources, evaporation, and sinks,
Fischer, Lucas, Wirth, M., Kiemle, C., Schäfler, Andreas, Craig, George   +4 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Vibration of Circular Metal-Polymeric Plates on an Elastic Foundation under Heat Stroke

Механика машин, механизмов и материалов, 2009
The axisymmetrical vibrations of elastic circular three-layer metal-polymeric plate on en elastic foundation ander heat stroke are explored. For the kinematics description asymmetrical on the thickness of package accepted hypothesises broken normal ...
Yu.M. Pleskachevsky , V.D. Kubenko , E.I. Starovoitov , D.V. Leonenko   +3 more
doaj