Results 131 to 140 of about 5,147,890 (313)

Scaling of Latitude‐Dependent Heat Transport in Geostrophic Convection

Geophysical Research Letters
Latitudinal variations in heat transport shape the thermal and magnetic evolution of rapidly rotating planets, stars, and icy moons. Although global simulations have revealed strong equatorial–polar contrasts, a predictive scaling theory has been lacking.
Veeraraghavan Kannan, Varghese Mathai, Xiaojue Zhu   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Pacific Arctic sea ice loss resulting from atmospheric circulation-driven ocean heat transport

Environmental Research Letters
Arctic sea ice is disappearing rapidly, but the melt comes from two different pathways: direct surface warming and the movement of warm water into the Arctic. This study focuses on the latter, i.e.
Yungi Hong, S-Y Simon Wang, Jin-Ho Yoon
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Thermal conductivity of nickel superalloy MAR-M247

Metalurgija, 2016
The paper presents the narrow connection between γ’ phase dissolving and values of thermal conductivity. In annealing process the free space among γ’ particles (blocks) changes in certain cycle from fine to rough and back to fine.
P. Jonšta, P. Koštial, Z. Jonšta, I. Vlčková, T. Kulová   +4 more
doaj  

Vestibular Patient Journey: Insights From Vestibular Disorders Association (VeDA) Registry

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Vestibular symptoms impose a high burden of disability. Understanding real‐world diagnostic and treatment pathways can identify care gaps and guide interventions. We aimed to characterize symptom profiles, diagnostic trends, provider involvement, and treatment patterns in vestibular disorders.
Ali Rafati, Sami I. Nassar, Shaun A. Nguyen, Patricia L. Gerend, Michael C. Schubert, Michael T. Teixido, Frederick A. Godley, Joel A. Goebel, Cynthia A. Ryan, Habib G. Rizk, Amir Kheradmand   +10 more
wiley   +1 more source

Experimental study and gyrokinetic simulations of isotope effects on core heat transport in JET tokamak deuterium and tritium plasmas

Nuclear Fusion
This paper presents a study on the dependence of the ion temperature stiffness on the plasma main ion isotope mass in JET ITER-like wall and C wall discharges.
D. Brioschi, P. Mantica, A. Mariani, N. Bonanomi, E. Delabie, J. Garcia, N. Hawkes, I. Jepu, D. Keeling, E. Lerche, E. Litherland-Smith, C.F. Maggi, S. Menmuir, G. Szepesi, D. Taylor, D. Van Eester, JET Contributors   +16 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Impact of groundwater extraction on subsurface thermal regimes

Environmental Research Letters
Groundwater is widely exploited, leading to groundwater depletion, and a reduction of river flows. While the impact of climate change and hydrologic forcings on the hydrogeological cycle has long been demonstrated, a lack of observations of subsurface ...
Maria Klepikova, Victor Bense, Tanguy Le Borgne, Nicolas Guihéneuf, Olivier Bour   +4 more
doaj   +1 more source

Clinical Outcomes of SEEG‐Guided Radiofrequency Thermocoagulation in Children With Focal Drug‐Resistant Epilepsy: A Multicenter Real‐World Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Stereoelectroencephalography‐guided radiofrequency thermocoagulation (SEEG‐RFTC) has emerged as a safe and effective minimally invasive treatment for children with drug‐resistant focal epilepsy. Although evidence from real‐world studies remains limited, numerous pediatric cases have demonstrated promising outcomes. This retrospective
Weitao Chen, Stéphane Jean, Weihong Liu, Yihai Dai, Xinrong Fang, Xiaoqiang Wei, Shan Chen, Shiwei Song   +7 more
wiley   +1 more source