Results 61 to 70 of about 9,345 (219)

Dynamics of Circular Metal-Polymeric Plates on an Elastic Foundation. Part I. FREE VIBRATIONS

Механика машин, механизмов и материалов, 2008
The axisymmetrical free vibrations of elastic circular three-layer metal-polymeric plate on en elastic foundation are explored. Reaction of foundation was described on the base of Winkler’s model.
Yu.M. Pleskatshevsky, E.I. Starovoitov , D.V. Leonenko   +2 more
doaj  

Heat Content Anomaly and Decay of Warm‐Core Rings: the Case of the Gulf of Mexico

Geophysical Research Letters, 2020
In this study, we harness the 25‐year satellite‐altimeter record, in concert with a vast array of in situ measurements, to estimate the heat content anomaly of 32 warm‐core rings in the Gulf of Mexico (GoM).
Thomas Meunier, Julio Sheinbaum, Enric Pallàs‐Sanz, Miguel Tenreiro, José Ochoa, Angel Ruiz‐Angulo, Xavier Carton, Charly de Marez   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Modeling the Operating Conditions of Electric Power Systems Feeding DC and AC Traction Substations

Energies
This paper presents the findings of the research aimed at developing computer models to determine the operating conditions in electric power systems (EPSs) feeding DC and AC railway substations.
Iliya K. Iliev, Andrey V. Kryukov, Konstantin V. Suslov, Aleksandr V. Cherepanov, Nguyen Quoc Hieu, Ivan H. Beloev, Yuliya S. Valeeva   +6 more
doaj   +1 more source

Entropy Generation Analysis and Thermodynamic Optimization of Jet Impingement Cooling Using Large Eddy Simulation

Entropy, 2019
In this work, entropy generation analysis is applied to characterize and optimize a turbulent impinging jet on a heated solid surface. In particular, the influence of plate inclinations and Reynolds numbers on the turbulent heat and fluid flow properties
Florian Ries, Yongxiang Li, Kaushal Nishad, Johannes Janicka, Amsini Sadiki   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Modeling of Electromagnetic Fields of the Traction Network Taking into Account the Influence of Metal Structures

Applied Sciences
The paper addresses the issues of electromagnetic safety in traction networks of 25 kV AC railways. The purpose of the research is to develop digital models to determine the strengths of electromagnetic fields (EMFs) created by traction networks near ...
Iliya Iliev, Andrey Kryukov, Konstantin Suslov, Ekaterina Voronina, Andrey Batukhtin, Ivan Beloev, Yuliya Valeeva   +6 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Influence of Engine Load on Soot Mass Concentration and Morphology in Diesel Exhaust

Atmosphere
This study investigates the relationship between exhaust gas composition, particle number (PN) emissions, and soot microstructure of a 1.9 L compression-ignition engine operated under six controlled steady-state load regimes at 2000 min−1.
Iliyan Damyanov, Evgeni Dimitrov, Hristo Konakchiev, Iliyan Ognyanov   +3 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source