Results 91 to 100 of about 3,845,354 (297)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Applied SciencesThe paper addresses the issues of electromagnetic safety in traction networks of 25 kV AC railways. The purpose of the research is to develop digital models to determine the strengths of electromagnetic fields (EMFs) created by traction networks near ...
Iliya Iliev +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Influence of Engine Load on Soot Mass Concentration and Morphology in Diesel Exhaust
AtmosphereThis study investigates the relationship between exhaust gas composition, particle number (PN) emissions, and soot microstructure of a 1.9 L compression-ignition engine operated under six controlled steady-state load regimes at 2000 min−1.
Iliyan Damyanov +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Investigation Perspectives of Dynamics of Tank Vehicles for Liquid Loads
Механика машин, механизмов и материалов, 2007 It is analysed a current state and investigation perspectives of dynamics truck and rail tank vehicles. There are resulted equations presenting movement of considered system members.
A.O. Shimanovsky +2 more
doaj
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Heat current control in trapped Bose–Einstein Condensates
New Journal of Physics, 2019 We investigate the heat transport and the control of heat current among two spatially separated trapped Bose–Einstein Condensates (BECs), each of them at a different temperature.
C Charalambous +3 more
doaj +1 more source