Results 201 to 210 of about 3,829,895 (295)

Dimerization of human PARP15 is required for NAD+ binding and automodification

The FEBS Journal, EarlyView.
This study provides an integrated structural model of human PARP15. Biophysical, enzymatic, and cell‐based analyses identify the dimer as the active oligomeric state capable of binding the substrate NAD+. A co‐crystal structure with a non‐hydrolyzable substrate analog BAD reveals the molecular basis for the dimerization requirement.
Anna Tuovinen, Johan Pääkkönen, Mirko M. Maksimainen, Lea Hirschen, Heli I. Hentilä, Marie Tauscher, Bernhard Lüscher, Carlos Vela‐Rodríguez, Patricia Korn, Lari Lehtiö   +9 more
wiley   +1 more source

The Effects of Heated Tobacco Products on Oral Health and Quality of Life: An Observational Cross-Sectional Study. [PDF]

Healthcare (Basel)
Glavina A, Gravić A, Demo J, Martinović D, Tadin A, Lešić S, Šupe-Domić D.   +6 more
europepmc   +1 more source

Breaking the ice: multiple origins of ice‐binding/antifreeze proteins

The FEBS Journal, EarlyView.
Ice‐binding proteins (IBPs) evolved independently in many organisms during Cenozoic cooling and glaciation. In flounders, α‐helical IBPs evolved from an antiviral protein, while similar IBPs arose independently from different progenitors in three other fish lineages.
Laurie A. Graham, Peter L. Davies
wiley   +1 more source

Systematic Assessment of Flavor Cues and Additives in Cigarettes and Heated Tobacco Products in Korea: Cross-Sectional Surveillance Study. [PDF]

JMIR Public Health Surveill
Heo G, Kim D, Kim Y, Kim A, Cho N, Kang N, Park J, Cheon E, Kim S, Park S, Park S, Cho SI, Kang H.   +12 more
europepmc   +1 more source

The molecular basis of GshT substrate binding reveals how Streptococcus pneumoniae acquires the antioxidant glutathione

The FEBS Journal, EarlyView.
Streptococcus pneumoniae imports glutathione (GSH) from its obligate human host to defend against oxidative stress. GSH import is facilitated through the substrate binding protein (SBP) GshT, relying on charge complementarity between the protein and ligand.
Sarah E. du Toit, Paul E. Pace, Pierre De Cordovez, Christoph Göbl, Nina Dickerhof   +4 more
wiley   +1 more source

Impact of heated tobacco products on biomarkers of potential harm and adverse events: a systematic review and meta-analysis. [PDF]

Tob Control
Braznell S, Dance S, Hartmann-Boyce J, Gilmore A.   +3 more
europepmc   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Health Hazards of E-Cigarettes and Heated Tobacco Products: a Comprehensive Analysis of Hazardous Substances and Regulatory Gaps. [PDF]

Nicotine Tob Res
El Bouz M, Neto C, Mansuy T, Becher R, Valen H, Mariussen E, Blanco-Escauriaza DA, González-Marrón A, Zervas E, Havermans A, Talhout R, Staal YCM.   +11 more
europepmc   +1 more source

Decoding the “Metallic” Immune Imprint: Single‐Cell Exposomics Reveals the Immune Imprint of Fire Smoke

Allergy, EarlyView.
Takafumi Kubota, Yuki Matsumoto, Takahiro Tabuchi   +2 more
wiley   +1 more source

Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar, Diana Baumann, Sebastian Niedermeier, Rafaela L. Silva, Susanne Walch, Michael Schloter, Martin Köberle, Tilo Biedermann, Thomas Volz   +8 more
wiley   +1 more source