Results 101 to 110 of about 83,452 (308)

Carbon monoxide in exhaled air of students in Tehran

open access: yesSalāmat-i kār-i Īrān, 2010
Background and aimsCarbon monoxide poisoning is a major cause of mortality due to gasinhalation. It is more prevalent in winter, because of poor indoor ventilation.
M. Kazempour   +3 more
doaj  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Ninety - Two Percent Minimum Heater Efficiency By 1980

open access: yes, 1980
Technology is now available to increase heater efficiencies to 92 percent and more. By 1980, this technology will be field proven and corrosion and reliability problems identified and resolved.
Hardie, J. E., Mieth, H. C.
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Comparison of aluminium and stainless steel built-in-storage solar water heater

open access: yes, 2007
This article provides the results and findings of an experimental work undertaken in Pakistan that aimed to compare the performance of stainless steel and aluminium make built-in-storage solar waters.
Muneer, T., Asif, M., Currie, J.
core   +1 more source

Nanoscale heat generation in a single Si nanowire

open access: yesNanophotonics
We develop a nanoheater utilizing a single Si nanowire with a porous segment that produces localized heat. The 19-fold higher resistivity of the porous segment compared to the solid segment in the nanowire facilitates the substantial confinement of heat ...
Kim Jungkil   +2 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Patio heaters

open access: yes, 2015
The Perch is an AMS owned rooftop restaurant in the new student union building. The patio was originally only meant for summertime use, however AMS would like to extend patio use into the spring and autumn seasons. Conventional restaurant standard is to use propane heaters but due to the new LEED certification requirements, sustainability is the main ...
Cornell, Dylan   +2 more
openaire   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

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