Results 31 to 40 of about 76,203 (257)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Alternative to the Conventional Heating and Cooling Systems in Public Buildings [PDF]

open access: yes, 2010
The paper presents an alternative system for heating and cooling in public buildings. The system was designed for the retrofitted building of the Slovene Ethnographic Museum (SEM) where it was also extensively tested.
Dovjak, Mateja   +4 more
core  

Solar Decathlon Latin America and Caribbean: Comfort and the Balance between Passive and Active Design [PDF]

open access: yes, 2019
This article contains an overall analysis of the results obtained by the four highest scoring teams in the Solar Decathlon Latin America and Caribbean 2015 collegiate sustainable habitat competition. Considering that the prototypes developed were based
Herrera-Limones, Rafael   +2 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Air exchanges, climate change, and severe acute respiratory coronavirus virus 2 (SARS-CoV-2): Results from a survey of the Society of Healthcare Epidemiology of America Research Network (SRN)

open access: yesAntimicrobial Stewardship & Healthcare Epidemiology, 2022
In this cross-sectional survey, we assessed knowledge, attitudes and behaviors regarding operating room air-change rates, climate change, and coronavirus disease 2019 (COVID-19) pandemic implications.
Jason P. Burnham   +6 more
doaj   +1 more source

The Histoty of Ventilation and Air Conditioning: is CERN Up to Date with the latest Technological Developments? [PDF]

open access: yes, 2000
The invention of ventilation cannot be ascribed to a certain date. It started with simple aeration when man brought fire into his abode and continued through different stages including air cooling using ice to finally arrive at the time when ventilation ...
Kühnl-Kinel, J
core  

Corrosion and Process Analysis of a Preoxidized MgO Recyclate‐Based Cermet Anode in Laboratory‐Scale Na‐Cryolite Molten Salt Electrolysis of Aluminum at 1000°C

open access: yesAdvanced Engineering Materials, EarlyView.
EDX elemental map of the pre‐oxidized MgO–steel cermet anode cross section after electrolysis. The development of inert anodes for aluminum electrolysis remains challenging due to the high corrosivity of cryolite‐based melts at 950°C–1000°C. This study investigates the corrosion and process behavior of a carbon‐free MgO–steel cermet anode derived from ...
Alexander Adamczyk   +7 more
wiley   +1 more source

Enhancing smart readiness of buildings: bridging the knowledge gap to European citizens

open access: yesInternational Journal of Sustainable Energy
This study delves into the Smart Readiness Indicator (SRI), an innovative measure designed to assess and enhance the smart capabilities of buildings across Europe.
Afroditi Zamanidou   +7 more
doaj   +1 more source

Regulations and robust low-carbon buildings [PDF]

open access: yes, 2009
Building regulations and associated calculation methods have been rapidly evolving, driven in Europe by the European Union Energy Performance of Buildings Directive. As an example, the current UK regulations are explored in relation to buildings that are
Tuohy, Paul
core   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He   +10 more
wiley   +1 more source

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