Results 21 to 30 of about 16,042 (204)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Conservatories and domestic heating [PDF]

open access: yes, 1987
Passive solar gains to buildings in North European Climates can be significant and an investigation is made into the effect of orientation upon solar gains based upon known weather data.
Felgate, G.B, Felgate, G.B.
core  

The ‘District Heating Wall’:a synergistic approach to achieve affordable carbon emission reductions in old terraced houses

open access: yes, 2012
One effective method to help the UK achieve GHG emission reduction targets is to reduce and decarbonise the heat demand of solid-walled terraced houses, as there are over 2.5 million such buildings making up a significant proportion of the whole building
Frost, Claire   +3 more
core   +1 more source

Effect of lift-up design on pedestrian level wind comfort around isolated building under different wind directions [PDF]

open access: yes, 2018
10th International Symposium on Heating, Ventilation and Air Conditioning, ISHVAC 2017, Jian, China, 19-22 October, 2017201803 bcmaVersion of ...
Du, Y, Mak, CM
core   +1 more source

Analysis of Typical Meteorological Year selection for energy simulation of building with daylight utilization

open access: yes, 2023
10th International Symposium on Heating, Ventilation and Air Conditioning, ISHVAC2017, 19-22 October 2017, Jinan, China202311 bckwVersion of RecordNot ...
Li, Z, Xiao, F, Sun, J
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Natural ventilation and cooling by evaporation in hot-arid climates [PDF]

open access: yes, 1990
In hot climates, outside air is too hot during the day. In hot arid climates, low humidity increases discomfort. For comfort, hot air should be cooled before flowing into dwellings and moisture in the moving air increased.
Aboul Naga, Mohsen M, Aboul Naga, M.M
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller   +14 more
wiley   +1 more source

Cost effective combined axial fan and throttling valve control of ventilation rate [PDF]

open access: yes, 2004
This paper is concerned with Proportional-Integral-Plus (PIP) control of ventilation rate in mechanically ventilated agricultural buildings. In particular, it develops a unique fan and throttling valve control system for a 22m3 test chamber, representing
Leigh, P.   +5 more
core  

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