Results 81 to 90 of about 549,280 (285)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

U.S. commercial electricity consumption [PDF]

Commercial electricity usage exceeds that of industrial usage and is almost as large as residential electricity consumption in the United States. In this study, regional economic, demographic, and climatic data are used to analyze commercial electricity ...
Contreras, Sergio, Fullerton, Thomas M., Jr., Smith, Wm. Doyle   +2 more
core   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Degree-Day Climatology over Central and Southeast Europe for the Period 1961-2018 – Evaluation in High Resolution

Cybernetics and Information Technologies, 2020
The ongoing climate change over Central and Southeast Europe has a great potential to affect significantly the public energy demands and in particular the energy consumption in the residential heating and cooling sector.
Chervenkov Hristo, Ivanov Vladimir, Gadzhev Georgi, Ganev Kostadin, Melas Dimitrios   +4 more
doaj   +1 more source

SINGLE FACTOR STOCHASTIC MODELS WITH SEASONALITY APPLIED TO UNDERLYING WEATHER DERIVATIVES VARIABLES [PDF]

This paper estimates single factor stochastic models describing daily air temperature behaviour. We modify classical financial models to reflect temperature seasonality and fit them to a time series representing temperatures in Spain.
Enric Valor, Hipòlit Torró, Vicente Meneu   +2 more
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Evaluation and Projection of Degree-Days and Degree-Days Categories in Southeast Europe Using EURO-CORDEX

Atmosphere
The temperature-based indicators heating and cooling degree days, are frequently utilized to quantitatively link indoor energy demand and outdoor thermal conditions, especially in the context of climate change.
Hristo Chervenkov, Kiril Slavov
doaj   +1 more source

Application of Building Typologies for Modelling the Energy Balance of the Residential Building Stock [PDF]

, 2012
Building typologies can serve as a basis for analysing the national housing sector. During the TABULA project which was introducing or further developing building typologies in thirteen EU countries, six of the European partners have carried out model ...
Balaras, C., Ballarini, Ilaria, Corgnati, Stefano Paolo, Corrado, Vincenzo, Dascalaki, E., Diefenbach, N., Kragh, J., Loga, T., Rakušček, A., Renders, N., Vimmr, T., Wittchen, K.B., Šijanec Zavrl, M.   +12 more
core  

Household electricity demand in Spanish regions. Public policy implications [PDF]

, 2014
This paper analyses the determinants of household electricity demand with a panel data, partial adjustment model of Spanish regions in the 1998-2009 period.
Peñasco, Cristina, Romero Jordán, Desiderio, Río González, Pablo del   +2 more
core   +1 more source