Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
On the Investigation of Effective Factors on Higher Heating Value of Biodiesel: Robust Modeling and Data Assessments. [PDF]
Biomed Res Int, 2021 Wang S, Li W, Alruyemi I.
europepmc +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Predicting the high heating value and nitrogen content of torrefied biomass using a support vector machine optimized by a sparrow search algorithm. [PDF]
RSC Adv, 2023 Xiaorui L, Jiamin Y, Longji Y.
europepmc +1 more source
Aerodynamic pressure and heating-rate distributions in tile gaps around chine regions with pressure gradients at a Mach number of 6.6 [PDF]
Surface and gap pressures and heating-rate distributions were obtained for simulated Thermal Protection System (TPS) tile arrays on the curved surface test apparatus of the Langley 8-Foot High Temperature Tunnel at Mach 6.6.
Hunt, L. Roane, Notestine, Kristopher K.
core +1 more source
Many-body dynamics and gap opening in interacting periodically driven systems
, 2017 We study the transient dynamics in a two-dimensional system of interacting Dirac fermions subject to a quenched drive with circularly polarized light. In the absence of interactions, the drive opens a gap at the Dirac point in the quasienergy spectrum ...
Kandelaki, Ervand, Rudner, Mark S.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Economic and CO2 mitigation impacts of promoting biomass heating systems: an input-output study for Vorarlberg, Austria [PDF]
This paper reports on an empirical investigation about the economic and CO2 mitigation impacts of bioenergy promotion in the Austrian federal province of Vorarlberg.
Martin Koller, Reinhard Madlener
core
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Utilization of wood and bark of fast-growing hardwood species in energy production
Journal of Forest Science, 2018 In this research, the calorific value and ash content of wood and bark of some fast-growing hardwood species, such as tree-of-heaven, (Ailanthus altissima (Miller) Swingle), empress tree (Paulownia tomentosa (Thunberg) Steudel), trembling aspen (Populus ...
Vasiliki KAMPERIDOU +2 more
doaj +1 more source