Results 81 to 90 of about 12,484 (206)

The XX Factor in Hemophilia: Diagnostic, Therapeutic, and Research Gaps for Women and Girls

Haemophilia, EarlyView.
ABSTRACT Introduction Hemophilia has traditionally been viewed as an X‐linked disorder affecting men and boys, with women and girls labeled as “carriers”, presumed to be clinically unaffected. This paradigm has contributed to under‐recognition, delayed diagnosis, and undertreatment of females with hemophilia‐associated genotypes despite an increasingly
Kelsey Uminski, Ellen Cusano
wiley   +1 more source

Cyclical progestogens for heavy menstrual bleeding

Cochrane Database of Systematic Reviews, 2019
Heavy menstrual bleeding (HMB) is a menstrual blood loss perceived by women as excessive that affects the health of women of reproductive age, interfering with their physical, emotional, social and material quality of life. Whilst abnormal menstrual bleeding may be associated with underlying pathology, in the present context, HMB is defined as ...
Magdalena, Bofill Rodriguez, Anne, Lethaby, Cindy, Low, Iain T, Cameron   +3 more
openaire   +3 more sources

DDAVP Challenges in 170 Children With von Willebrand Disease: Response Classification Varies According to Criteria Used

Haemophilia, EarlyView.
ABSTRACT Introduction Individuals diagnosed with types 1/1C/2A/2M von Willebrand disease (VWD) typically undergo a desmopressin (DDAVP) challenge to assess therapeutic benefit. This involves measuring von Willebrand factor antigen (VWF:Ag), activity (VWF:Act; VWF:RCo/VWF:GPIbM/VWF:Ab), and coagulant factor VIII (FVIII:C) levels 0 (pre), 1, and 4‐h post‐
Michael Shu, Caroline Malcolmson, Amanda Fregonas, Tristan E. Knight, Margaret L. Rand, Cindy Wakefield, Vanessa Bouskill, Manuel Carcao   +7 more
wiley   +1 more source

Underdiagnosis of Von Willebrand Disease: The Silent Majority of Women in Brazil

Haemophilia, EarlyView.
Abstract Introduction Von Willebrand disease (VWD) is the most common inherited bleeding disorder. Although autosomal inheritance predicts a similar distribution between sexes, women are more often diagnosed due to hemostatic challenges associated with menstruation and childbirth.
Yara Maria da Silva Pires, Gabriel Iamassaki Staquicini de Paula, Thyago César da Silva Pires   +2 more
wiley   +1 more source

Impact of demographic and clinical factors on elagolix plus add-back therapy effects on patient-reported nonbleeding symptoms in women with heavy menstrual bleeding and uterine fibroids: a post hoc analysis of data from two clinical trials

F&S Reports
Objective: To investigate the efficacy of elagolix plus add-back therapy (estradiol [1 mg] and norethindrone acetate [0.5 mg] once daily) on patient-reported nonbleeding symptoms and menstrual bleeding associated with uterine fibroids (UFs) across ...
James A. Simon, M.D., Elizabeth A. Stewart, M.D., Susan Jewell, Ph.D., Moming Li, Ph.D., Michael C. Snabes, M.D., Ph.D.   +4 more
doaj   +1 more source

Severe Thrombocytopenia Associated With Glucagon‐Like‐1 Receptor Agonists (GPL‐1RA): A SONAR Report

Diabetes, Obesity and Metabolism, EarlyView.
Charles L. Bennett, Chadi Nabhan, Demir Uslu, Yogitha Dadi, David Aboulafia, Barbara Senger, Joseph Magagnoli, Kelvin Rojas, Gurdeep Singh, Linda Martin, Edward Smith, Samuel Ruder, Chien‐Hsiang Weng, Nikhil Uppal, Mia Lynch, James B. Bussel   +15 more
wiley   +1 more source

Risk of Postpartum Hemorrhage in Women With Von Willebrand Disease: A Real‐World Data Analysis

Haemophilia, EarlyView.
ABSTRACT Introduction Women with von Willebrand disease (VWD) are at increased risk for postpartum hemorrhage (PPH), but contemporary United States data on maternal outcomes and real‐world peripartum treatment patterns are limited. Aim To evaluate maternal outcomes associated with claims‐recorded VWD in a national claims cohort and describe exploratory
Mayank Patel, Victor Zibara, Craig Seaman, Sruti Shiva, Nicoletta C. Machin   +4 more
wiley   +1 more source

Heavy menstrual bleeding on rivaroxaban [PDF]

British Journal of Haematology, 2015
Ferreira, Melanie, Barsam, Sarah Joy, Patel, Jignesh Prakash, Czuprynska, Julia, Roberts, Lara, Patel, Raj K, Arya, Roopen   +6 more
openaire   +3 more sources

Living With Factor VII Deficiency—A Mixed Methods Study

Haemophilia, EarlyView.
ABSTRACT Background Factor VII deficiency (FVIID) is a rare autosomal recessive disorder, resulting in potentially unpredictable and life‐threatening bleeding. The prevalence of symptomatic patients is 1 in 300,000. Treatment is mostly given following bleeding, but those with the lowest levels may be offered prophylaxis.
Simon Fletcher, Matthew Boyton, Sam Bristow, Kate Khair   +3 more
wiley   +1 more source

Generational Differences in Illness‐Related Uncertainty Among Haemophilia Carriers: A Qualitative Study Using Mishel's Uncertainty in Illness Theory

Haemophilia, EarlyView.
ABSTRACT Aim Haemophilia carriers (HCs) have historically been regarded as asymptomatic or only mildly affected, resulting in under‐recognition of bleeding symptoms and unmet healthcare needs. Although advances in healthcare and access to information have changed the experience of haemophilia, little is known about how illness‐related uncertainty ...
Tomie Fujii, Teruhisa Fujii, Teiji Uchino   +2 more
wiley   +1 more source