Targeting DNA‐LNPs to Endothelial Cells Improves Expression Magnitude, Duration, and Specificity
Advanced Science, EarlyView.Attaching antibodies against endothelial cell surface proteins redirects the delivery and expression of DNA‐lipid nanoparticles to organs of interest. Our targeted nanoparticles enable organ‐selective DNA expression in the endothelium of the lungs, brain, or spleen, providing a therapeutic platform for dozens of endothelial‐centric diseases.
Nicolas Marzolini +24 more
wiley +1 more source
Does the use of hedge derivatives improve the credit ratings of Brazilian companies?
Revista Contabilidade & FinançasThe purpose of this study is to identify the factors that may explain the attribution of credit ratings to firms, focusing especially on the impact of derivatives.
Rafael Moreira Antônio +3 more
doaj +1 more source
Banking accounts volatility induced by IAS 39: A simulation model applied to the French case. [PDF]
La décision de l’Union européenne d’adopter les normes IAS pour l’ensemble de ses membres, avait été fortement contestée par les banques européennes.
Ben Hamida, Nessrine
core
Accounting for financial instruments in the banking industry: conclusions from a simulation model [PDF]
, 2003 The paper analyses the effects of three sets of accounting rules for financial instruments - Old IAS before IAS 39 became effective, Current IAS or US GAAP, and the Full Fair Value (FFV) model proposed by the Joint Working Group (JWG) - on the financial ...
Gebhardt, Günther +2 more
core
EGR Proteins Mediate Interferon‐Independent Anti‐HSV‐1 Responses Through Viral and Host Targets
Advanced Science, EarlyView.Early antiviral responses are typically mediated by interferons. However, during HSV‐1 infection, host early growth response (Egr) genes, which are not interferon‐stimulated genes, are quickly induced by viral protein ICP0. EGR proteins, in turn, suppress viral lytic infection by activating viral latency‐associated (LAT) and host immune regulatory ...
Shuaishuai Wang +4 more
wiley +1 more source
Derivatives and Risk Management in the Banking Industry
The International Journal of Banking and Finance, 2004 The purpose of this study is to examine issues surrounding the enactment of Financial Accounting Statement 133 (SFAS 133) in managing risk in the banking industry. It examined the financial statements of ten major U.S.
Abraham Mulugetta, Hristo Hadjinikolov
doaj
Exploring Bitcoin dynamics against the backdrop of COVID-19: an investigation of major global events
Financial InnovationCOVID-19 has significantly influenced global financial markets, including Bitcoin. Recent studies have focused on investigating the first wave of the COVID-19 outbreak and accounting for market changes, which were mostly due to the pandemic.
Xiaochun Guo
doaj +1 more source
Analysis of energy loss in the helical hedge flow channel of fruit tree root emitter. [PDF]
Sci Rep, 2023 Zhang J, Li X, Zhang S, Zhang M.
europepmc +1 more source
S3RL: Enhancing Spatial Single‐Cell Transcriptomics With Separable Representation Learning
Advanced Science, EarlyView.Separable Spatial Representation Learning (S3RL) is introduced to enhance the reconstruction of spatial transcriptomic landscapes by disentangling spatial structure and gene expression semantics. By integrating multimodal inputs with graph‐based representation learning and hyperspherical prototype modeling, S3RL enables high‐fidelity spatial domain ...
Laiyi Fu +6 more
wiley +1 more source
Optimal allocation of resources between control and surveillance for complex eradication scenarios
Methods in Ecology and EvolutionTo ensure the success of complex invasive‐species eradication programs across large areas, efficient and effective resource allocation is crucial. This study incorporates analytical Bayesian solutions and measures of uncertainty into a framework of ...
Mahdi Parsa +2 more
doaj +1 more source