Results 171 to 180 of about 4,261 (299)

Agentic Finance: An Adaptive Inference Framework for Bounded-Rational Investing Agents. [PDF]

Entropy (Basel)
Montañez Jacquez S, Clippinger JH, Moroney M.   +2 more
europepmc   +1 more source

Molecular Glue cc‐885 Inhibits VHL‐Deficient Clear Cell Renal Cell Carcinoma via ETS1 Degradation

Advanced Science, EarlyView.
VHL‐deficient kidney cancer lacks effective treatments. This study reveals that the molecular glue degrader cc‐885 hijacks the cellular recycling system to selectively destroy the oncogenic protein ETS1, effectively killing VHL‐mutant tumors. Combining CC‐885 with the approved drug belzutifan achieves powerful synergy, offering a promising new ...
Taowei Yang, Qihao Li, Kun Ye, Kezhi Liu, Mi Zhou, Minyu Chen, Lican Liao, Kangbo Huang, Zhu Wang, Qiong Deng, Jieyan Wang, Meiyu Jin, Xu Chen, Hui Liang, Jiaxing Zhang, Junhang Luo   +15 more
wiley   +1 more source

Interstage market spillovers of the photovoltaic industry chain in China. [PDF]

Sci Rep
Wang J, Li L, Shen T.
europepmc   +1 more source

The model of hedge effectiveness assessment

, 2008
Darba mērķis ir izpētīt starptautiskās konsultantu kompānijas PricewaterhouseCoopers piedāvāato modeli hedžēšanas darījumu prospektīvas efektivitātes novērtēšanai, veikt uzlabojumus.
Kupce, Anitra
core  

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Changes in the network structure of energy markets and financial markets under the different shocks of the Russia-Ukraine conflict and COVID-19. [PDF]

PLoS One
Li F, Tong M, Guan S.
europepmc   +1 more source

Local Polynomial Kernel Forecasts and Management of Price Risks using Futures Markets

This study contributes to understanding price risk management through hedging strategies in a forecasting context. A relatively new forecasting method, nonparametric local polynomial kernel (LPK), is used and applied to the hog sector.
Kim, MinKyoung, Garcia, Philip, Leuthold, Raymond M.   +2 more
core  

Full‐Body AI Agent: A Perspective on Multi‐Scale Collaborative AI for Systemic Biology and Precision Medicine

Advanced Science, EarlyView.
We propose the Full‐Body AI Agent, a multi‐scale collaborative framework with 7 biological‐layer agents. It unifies multi‐omics/clinical data via standardized protocols, enabling phenotype‐guided closed‐loop reasoning, quantitative evaluation, and LLM safeguards, with promising applications in tumor metastasis modeling and precision drug development ...
Aoqi Wang, Jiajia Liu, Jianguo Wen, Yangyang Luo, Zhiwei Fan, Liren Yang, Xi Hu, Ruihan Luo, Yankai Yu, Sophia Li, Weiling Zhao, Xiaobo Zhou   +11 more
wiley   +1 more source

The Children's Urgent Reduction of Forearm Fractures in the Emergency Department (CURFFED) project : a national prospective trainee-led collaborative audit of practice. [PDF]

Bone Jt Open
Gourbault LJ, Whitham R, Womersley A, Jones E, Christie A, Duggleby L, Atherton WG, CURFFED Collaborative, Doughty B, Smith I, Hassan AR, Levitt W, Davies A, Carpenter C, Saltanat S, Buddhdev P, Lennox-Warburton H, Donnelly E, Kim K, Farooq J, Dean CS, Edwards C, Mahmoud M, Stone A, Oyekan A, Jalgaonkar A, To C, Hunt A, Garner M, Campion A, Sison M, Irby S, Price M, Sharoff L, Worley R, Tahir H, Bircher A, Modi N, Theobald E, Genena A, Carter D, Milnes L, Roberts T, Vasudev A, Green D, Boucher A, Caruana E, Khokhar O, Kumar P, Rahman H, Seewoonarain S, Thumbadoo R, Forster S, Vadivelu R, Bagshaw L, Varghese B, Thalanki S, Franco AC, Hamid L, Liew I, Robinson J, Gurung I, Figg P, Moverley R, Neal-Smith G, Barot K, Oo TP, Hanger J, Larsen M, Jones A, Lougher L, Flintoft-Burt M, Dellis S, Kamal T, Bajaj S, Chema K, Lebe M, Bhandari G, Jeans E, James K, Barrow T, Fernandez L, Razemba T, Hawkins R, Anderson K, Tillotson L, Thomas W, Burden E, Kadambande S, Ibrahim IK, O'Boyle M, McCormack L, O'Donnell J, Baird E, MacDonald F, Aithie J, Robinson P, Esland J, Keightley A, Jain A, Thakker D, Nayak M, Caamina L, Barrow T, Discalicau D, Lockton Z, Burgan A, Morris G, Bansal R, Sinha M, Mostafa O, Ishaq U, Elmorsy A, Thomas A, Ross P, Theivendran K, Khaleeq T, Lindisfarne E, Gangadharan R, Thiruchandran G, Youssef K, Tober A, Shah N, Varasteh A, Bajracharya A, Lashin A, Mifsud M, Lloyd T, Kirk C, Ball T, Sheen J, Kapoor S, Jones IT, Donnachie D, Clamp K, Westacott D, Miller J, Hedge E, Gomindes A, Amour L, Ibrahim J, Dwyer J, Bickley M, Fulcher E, Chourasia AK, Hosny S, Hashem M, Dutta A, Leong D, Fergurson K, Haddock A, Malik M, Varasteh A, Cruz L, Jenkins L, East J, Oxley C.   +156 more
europepmc   +1 more source

Genome‐Wide In Vivo RNAi Screening Identifies HOXD4 as a Tumor Metastasis Suppressor in Colorectal Cancer

Advanced Science, EarlyView.
Metastasis remains a major challenge in colorectal cancer. Using an in vivo shRNA screening system, this study identifies Homeobox D4 as a key metastasis suppressor. Reduced Homeobox D4 expression is associated with aggressive tumor features. Functional and mechanistic analyses show that it inhibits epithelial‐mesenchymal transition by repressing ...
Zhi‐hua Ye, Wen‐jing Luo, Lu Li, Wen‐di Shuai, Ling Zhou, You‐fa Duan, Xue Chen, Jun‐kai Zhang, Wenlin Huang, Ran‐yi Liu   +9 more
wiley   +1 more source