Results 241 to 250 of about 4,261 (299)

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, EarlyView.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Moving beyond a legacy paradigm: A vision for equitable access to quality medicines in Africa. [PDF]

Int J Gynaecol Obstet
Doi N, Orji BC, Ruffo M, Mukumbayi P, Kibonge S, Muthamia MM, Tappis H, Biayi F, Kassim TY, Ndwiga A.   +9 more
europepmc   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Validation of an interprofessional education search strategy in PubMed to optimize IPE literature searching. [PDF]

J Med Libr Assoc
Carlson R, Nachman S, Zerden LS, Mani N.
europepmc   +1 more source

Reviewing ecosystems of evidence: synthesising the evidence on the commercial determinants of health from a complex systems perspective. [PDF]

Syst Rev
Tompson A, Thomas J, Rutter H, Blanchard L, Cott É, Glover RE, Knai C, Maani N, van Schalkwyk MCI, Welch V, Petticrew M.   +10 more
europepmc   +1 more source

Home electricity data generator (HEDGE): An open-access tool for the generation of electric vehicle, residential demand, and PV generation profiles. [PDF]

MethodsX
Charbonnier F, Morstyn T, McCulloch M.
europepmc   +1 more source

Exploring the Antibacterial, Anti-Inflammatory, and Antioxidant Properties of the Natural Food Supplement "<i>Protegol</i>" as a Supportive Strategy in Respiratory Tract Infections. [PDF]

Antibiotics (Basel)
Barbarossa A, Argentieri MP, Diella MV, Spinozzi E, Maggi F, Carrieri A, Corbo F, Rosato A, Carocci A.   +8 more
europepmc   +1 more source

Guiding policies for agricultural nitrous oxide emission reduction with behavioral insights and experimentation. [PDF]

NPJ Sustain Agric
Li T, Liu Y, Weersink A, Wagner-Riddle C.   +3 more
europepmc   +1 more source

Assessing the efficacy of mind mapping as a learning technique to enhance information retrieval in nursing students. [PDF]

J Educ Health Promot
Jabade M, Nadaf H.
europepmc   +1 more source