Results 171 to 180 of about 5,491 (298)
Advanced Science, EarlyView.This study shows anti‐CEACAM5 CAR T‐cells are ineffective against colorectal cancer (CRC) because of CEACAM5 sequestration at intercellular junctions and the thick tumour cell glycocalyx. Enzymatic treatments of CRC cell monolayer/tissue section with trypsin or hyaluronidase restore CEACAM5 availability, enhance CAR T‐cell activation, increase ...
Debasis Banik +13 more
wiley +1 more source
Exploration in 4-year-old children is guided by learning progress and novelty. [PDF]
Child DevPoli F, Meyer M, Mars RB, Hunnius S.
europepmc +1 more source
Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3
Advanced Science, EarlyView.In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang +16 more
wiley +1 more source
A Portrait of Hedge Fund Investors: Flows, Performance and Smart Money [PDF]
, 2005 Guillermo Baquero, Marno Verbeek
openalex
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Advanced Science, EarlyView.This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source
Effects of Landscape Compositional Heterogeneity and Spatial Autocorrelation on Environmental Niche and Dispersal in Simulated Organisms. [PDF]
Ecol EvolTardanico J, Hovestadt T.
europepmc +1 more source
Do Hot Hands Exist Among Hedge Fund Managers? An Empirical Evaluation
, 2010 Ravi Jagannathan +2 more
openalex +1 more source
Advanced Science, EarlyView.This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui +18 more
wiley +1 more source
The resilience of ethical assets against different uncertainty shocks. [PDF]
HeliyonHasan MB +4 more
europepmc +1 more source