Results 241 to 250 of about 5,491 (298)

HSP70 Interactome‐Mediated Proteolysis Targeting Chimera (HSP70‐PROTAC) for Ferroptosis‐Driven Cancer Treatment

Advanced Science, EarlyView.
This study reports a novel targeted protein degradation strategy termed “HSP70‐PROTAC” that recruits Hsc70 complex to a target protein for inducing degradation. Among them, GDAz‐3 exhibits effective GPX4 degradation activity via UPS/CMA processes, triggering ferroptosis‐driven anticancer activity in vitro and in vivo.
Jinyun Dong, Yulong Li, Hui Liang, Zumei Wu, Shiqun Wang, Yichao Wang, Jieyu Xu, Yanning Lan, Maohua Cai, Guangzhao Pan, Haiyan Yang, Kai Miao, Zhe‐Sheng Chen, Fangfang Tao, Xuelei Ma, Jiang‐Jiang Qin   +15 more
wiley   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

First Report of a Migratory Pest, the Fall Armyworm, Spodoptera frugiperda (JE Smith, 1797) (Lepidoptera, Noctuidae) from Bulgaria. [PDF]

Insects
Szanyi S, Barta M, Velchev D, Beshkov S, Mumford S, Todorov I, Nagy A, Varga Z, Tóth M, Toshova T.   +9 more
europepmc   +1 more source

Factors affecting the maximum outcome payments of social impact bonds. [PDF]

PLoS One
Wang H, Chao N, Chen J, Chen M, Fu T.
europepmc   +1 more source

Fundraising in the Hedge Fund Industry

Olga Obizhaeva
openalex   +1 more source

Cortisol, Anxiety, and TNFα Mediate the Relationship Between BMI and Executive Functions. [PDF]

Stress Health
Prunell-Castañé A, Jurado MÁ, Caldú X, Sender-Palacios MJ, Sánchez Garre C, Salas Gómez-Pablos P, Garolera M.   +6 more
europepmc   +1 more source

Habitat-Based Predictions of Bridle Shiner (<i>Notropis bifrenatus</i>) in the Northeastern United States. [PDF]

Ecol Evol
Katz LS, Coghlan SM, Carpenter MA, Kinnison MT, Zydlewski JD.   +4 more
europepmc   +1 more source

Investigation of alpha amylase inhibitors from Bidens pilosa L. by in silico and in vitro studies. [PDF]

In Silico Pharmacol
Galagali A, Patil VS, Hiremath K, Sampat GH, Patil R, Virge R, Harish DR, Hedge HV, Roy S.   +8 more
europepmc   +1 more source