Results 71 to 80 of about 1,860 (264)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

open access: yesFEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard   +12 more
wiley   +1 more source

Hedge Funds As a Alternative Investment Opportunities

open access: yesContemporary Economics, 2009
Hedge fund which became a popular alternative investment is a collective term for different types of investment fund. A common feature of these funds is that they have absolute earnings targets, that is they set targets for earnings irrespective of ...
Michał Falkowski
doaj  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

open access: yesFEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya   +2 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Modelo multifactor para analizar la exposición de los hedge funds a factores de riesgo macroeconómico

open access: yesEconomía Teoría y Práctica, 2015
Los hedge funds son fondos de inversión alternativa para grandes patrimonios e inversores institucionales. Dado que coexisten con los fondos tradicionales y otras entidades financieras en muchos de los mismos mercados y con los mismos activos, los hedge ...
Elitania Leyva Rayón
doaj  

Risk and Return in Hedge Funds and Funds-of-Hedge Funds: A Cross-Sectional Approach

open access: yesAustralasian Business, Accounting and Finance Journal, 2009
The objective of this study is to examine whether the available data on individual hedge funds (HFs) and funds-of-hedge funds (FOHFs) can reveal the risk-return trade-off and, if so, to find an appropriate risk measure that captures the cross-sectional variation in HF and FOHF returns and compare the risk-return relationship in HFs and FOHFs. Using the
openaire   +3 more sources

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

open access: yesFEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty   +13 more
wiley   +1 more source

Risk-Adjusted Impact of Administrative Costs on the Distribution of Terminal Wealth for Long-Term Investment

open access: yesThe Scientific World Journal, 2014
The impact of administrative costs on the distribution of terminal wealth is approximated using a simple formula applicable to many investment situations.
Montserrat Guillén   +3 more
doaj   +1 more source

The Hedge Fund Game.

open access: yes, 2016
This paper examines theoretical properties of incentive contracts in the hedge fund industry. We show that it is very difficult to structure incentive payments that distinguish between unskilled managers, who cannot generate excess market returns, and skilled managers who can deliver such returns. Under any incentive scheme that does not levy penalties
Foster, D, Young, H
openaire   +2 more sources

Hedge funds [PDF]

open access: yescritical perspectives on international business, 2013
Purpose– The paper's aim is to explore the impact of statistical arbitrage and high-frequency trading as hedge fund investment strategies that have a significant impact on the environment of corporations.Design/methodology/approach– The paper is a meta-analysis of the role of investment strategies within complex systems.Findings– The growth of hedge ...
openaire   +1 more source

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