Results 311 to 320 of about 201,870 (394)

Correction to Supporting Information for Kim et al., Signaling axis involving Hedgehog, Notch, and Scl promotes the embryonic endothelial-to-hematopoietic transition. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Signalling pathways in a nutshell: from pathogenesis to therapeutical implications in prostate cancer. [PDF]

Ann Med
Goncharov AP, Dicusari Elissaiou C, Ben Aharon Farzalla E, Akhvlediani G, Vashakidze N, Kharaishvili G.   +5 more
europepmc   +1 more source

Skeletal Maturity and Age‐Related Changes in Immune Cells and Circulatory Factors Impair Large‐Scale Bone Regeneration

Aging Cell, EarlyView.
Although the ribs are the only human bones capable of regenerating large‐scale defects, this remarkable ability declines with skeletal maturity and age. Here, we reproduce skeletal maturity and age‐related phenotypic changes in a mouse model of rib resection.
Luciana Yamamoto de Almeida, Catharine Dietrich, Ashleigh S. Hanner, Katelyn M. McTighe, Daniel Martin, NIDCD/NIDCR Genomics and Computational Biology Core, Todd Fairbanks, Thomas M. Link, John M. Le, Natasha Curry, Priyam Jani, Xin Gao, Wenli Yu, Francesca V. Mariani, Olivier Duverger, Janice S. Lee   +15 more
wiley   +1 more source

Primary cilia and inflammatory response: unveiling new mechanisms in osteoarthritis progression. [PDF]

Exp Biol Med (Maywood)
Sun Y, Luo Z, Fu Y, Ngo T, Wang W, Wang Y, Kong Y.   +6 more
europepmc   +1 more source

The Ecological Genome Project and the Promises of Ecogenomics for Society: Realising a Shared Vision as One Health

Bioethics, EarlyView.
ABSTRACT This paper develops a vision for The Ecological Genome Project: an aspirational, global endeavour to connect human genomic sciences with the ethos of ecological sciences. The Project's goal is to strengthen interdisciplinary networks that relate to diverse initiatives using genomic technologies, with respect to shared ethical frameworks and ...
Benjamin Capps, Ruth Chadwick, Yann Joly, Claire Lajaunie, Iva Hauptmannova, Susannah Mackenzie, John. J. Mulvihill, Elizabeth Mumford, Sonja A. Rasmussen, Kunal Sanghavi, Donrich W. Thaldar, James Yeates, Maud C. Quinzin, Zohar Lederman   +13 more
wiley   +1 more source

Inter- and Intra-Species Variation and Genetic Diversity of Flea Ectoparasites in Hedgehogs (Mammalia, Erinaceidae) Collected in Northern Algeria. [PDF]

Insects
Chebbah O, Souttou K, Ouachek K, Lounis M, Brun S, Izri A, Akhoundi M.   +6 more
europepmc   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Erratum: The Mechanism by Which Hedgehog Interacting Protein (HHIP) in Cancer-Associated Fibroblasts Regulate the Secretion of Inflammatory Factors Through the JAK1/STAT3 Pathway Affecting Prostate Cancer Stemness [Corrigendum]. [PDF]

J Inflamm Res
europepmc   +1 more source

Prevalence of genetic alterations in basal cell carcinoma patients resistant to Hedgehog pathway inhibitors: a systematic review. [PDF]

Ann Med
Untaaveesup S, Srichana P, Techataweewan G, Pongphaew C, Dendumrongsup W, Ponvilawan B, Nampipat N, Limwongse C.   +7 more
europepmc   +1 more source

System level network data and models attack cancer drug resistance

British Journal of Pharmacology, EarlyView.
Drug resistance is responsible for >90% of cancer related deaths. Cancer drug resistance is a system level network phenomenon covering the entire cell. Small‐scale interactomes and signalling network models of drug resistance guide directed drug development.
Márk Kerestély, Dávid Keresztes, Levente Szarka, Borbála M. Kovács, Klára Schulc, Dániel V. Veres, Peter Csermely   +6 more
wiley   +1 more source