Results 201 to 210 of about 2,340,031 (328)

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

Aging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox, Gongyu Shi, Neve Read, Mohamed T. Patel, Kepeng Ou, Zijia Liu, Jiahui Wu, Suci Cendanawati, Jenna Le Brun Powell, Pola Goldberg Oppenheimer, Lisa J. Hill, Lindsay B. Nicholson, Andrew D. Dick, Jian Liu   +13 more
wiley   +1 more source

HEDGEHOG AND ITS PATHWAY MEMBERS ARE MISEXPRESSED AND ACTIVE IN THE MAJORITY OF SPORADIC HUMAN PANCREATIC ADENOCARCINOMAS: A BIOLOGICALLY IMPORTANT PATHWAY AND POTENTIAL THERAPEUTIC TARGET.

, 2004
David E. Rosow, Oliver Strobel, Amanda Trainor, Carlos Fernández‐del Castillo, Andrew L. Warshaw, Sarah P. Thayer   +5 more
openalex   +1 more source

Quercetin Reduces Vascular Senescence and Inflammation in Symptomatic Male but Not Female Coronary Artery Disease Patients

Aging Cell, EarlyView.
In male patients undergoing CABG surgery, pretreatment with quercetin suppressed inflammaging and its associated inflammation, leading to improved endothelium‐dependent relaxation (measured ex vivo) and reducing new onset of post‐operative atrial fibrillation.
Pauline Mury, Olina Dagher, Annik Fortier, Ariel Diaz, Yoan Lamarche, Pierre‐Emmanuel Noly, Marina Ibrahim, Pierre Pagé, Philippe Demers, Denis Bouchard, Pierre‐Luc Bernier, Nancy Poirier, Emmanuel Moss, Nicolas Durrleman, Hughes Jeanmart, Michel Pellerin, Guillaume Lettre, Nathalie Thorin‐Trescases, Michel Carrier, Eric Thorin   +19 more
wiley   +1 more source

Oncogenic KRAS Activates Hedgehog Signaling Pathway in Pancreatic Cancer Cells [PDF]

, 2007
Zhenyu Ji, Fang Mei, Jingwu Xie, Xiaodong Cheng   +3 more
openalex   +1 more source

Genomic technologies and the diagnosis of 46, XY differences of sex development

Andrology, EarlyView.
Abstract Differences/disorders of sex development can be caused by disruptions to the molecular and cellular mechanisms that control development and sex determination of the reproductive organs with 1:100 live births affected. Multiple genes are associated with 46, XY differences/disorders of sex development that can cause varying clinical phenotypes ...
Firman Idris, Andrew H. Sinclair, Katie L. Ayers   +2 more
wiley   +1 more source

Indian hedgehog signaling pathway: Expression and regulation in pancreatic cancer

, 2004
Hany Kayed, Jörg Kleeff, Shereen Keleg, Junchau Guo, Knut Ketterer, Pascal O. Berberat, Nathalia A. Giese, Iréne Esposito, Thomas Giese, Markus W. Büchler, Helmut Frieß   +10 more
openalex   +1 more source

The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution [PDF]

, 2007
David Q. Matus, Craig R. Magie, Kevin Pang, Mark Q. Martindale, Gerald H. Thomsen   +4 more
openalex   +1 more source

A luminal non‐coding RNA‐based genomic classifier confirms favourable outcomes in patients with clinically organ‐confined bladder cancer treated with radical cystectomy

BJU International, Volume 135, Issue 4, Page 648-656, April 2025.
Objective To further evaluate a genomic classifier (GC) in a cohort of patients undergoing radical cystectomy (RC), as long non‐coding RNA (lncRNA)‐based genomic profiling has suggested utility in identifying a distinct tumour subgroup corresponding to a favourable prognosis in patients with bladder cancer.
Joep J. de Jong, James A. Proudfoot, Siamak Daneshmand, Robert S. Svatek, Vikram Narayan, Ewan A. Gibb, Elai Davicioni, Shreyas Joshi, Aaron Dahmen, Roger Li, Brant A. Inman, Paras Shah, Iftach Chaplin, Jonathan Wright, Yair Lotan   +14 more
wiley   +1 more source

Hedgehog signaling in cancer stem cells: a focus on hematological cancers

Stem Cells and Cloning: Advances and Applications, 2015
Victoria Campbell, Mhairi Copland Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, College of Medical, Veterninary and Life Sciences, University of Glasgow, Glasgow, UK Abstract: The stem cell paradigm was first demonstrated in
Campbell V, Copl, M
doaj  

Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas [PDF]

, 2007
Yue Hong Bian, Shu Huang, Ling Yang, Xiao Li, Jing Wu Xie, Hong Wei Zhang   +5 more
openalex   +1 more source