Results 241 to 250 of about 2,340,031 (328)

GANT61 Modulates Autophagy and Lipid Metabolism in Ovarian Cancer

Cell Proliferation, EarlyView.
GANT61 induced autophagy via the AKT pathway and promoted the accumulation of lipid droplets in both cell lines. The molecular mechanism behind this lipid accumulation appears to involve the mediation of SREBP1. Furthermore, the combination of GANT61 with CQ/Fatostatin significantly inhibited the proliferation and clonogenicity of SKOV3 and SKOV3PTX ...
Yibin Pan, Lingfeng Chen, Jinlu Shen, Shihao Hong, Xiaojing Guan, Xudong Ma, Rongrong Tang, Meifei Lu, Fangying Sun, Shanliang Shang, Yongdong Dai, Zhaokai Zhou, Songying Zhang, Jianhua Yang   +13 more
wiley   +1 more source

Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma [PDF]

, 2009
Daniel D. Von Hoff, Patricia LoRusso, Charles M. Rudin, Josina C. Reddy, Robert L. Yauch, Raoul Tibes, Glen J. Weiss, Mitesh J. Borad, Christine L. Hann, Julie R. Brahmer, Howard Mackey, B. Lum, Walter C. Darbonne, James C. Marsters, Frédéric J. de Sauvage, Jennifer A. Low   +15 more
openalex   +1 more source

Targeting the Hedgehog and Notch Signaling Pathways [PDF]

Journal of Thoracic Oncology, 2011
openaire   +3 more sources

Transforming growth factor‐β‐mediated regulation of atoh1‐expressing neural progenitors is involved in the generation of cerebellar granule cells in larval and adult zebrafish

Development, Growth &Differentiation, Volume 67, Issue 3, Page 149-164, April 2025.
Proliferating neural progenitor cells that generate granule cells are located in the molecular layer (ML) of the cerebellum. Among these, some atoh1c‐expressing cells begin to differentiate and migrate to the granular layer (GL), where they localize as mature granule cells.
Jui Chun Wang, Takashi Shimizu, Masahiko Hibi   +2 more
wiley   +1 more source

Multiple Ubiquitin-Dependent Processing Pathways Regulate Hedgehog/Gli Signaling: Implications for Cell Development and Tumorigenesis

, 2007
Lucia Di Marcotullio, Elisabetta Ferretti, Azzura Greco, Enrico De Smaele, Isabella Screpanti, Alberto Gulino   +5 more
openalex   +1 more source

Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway [PDF]

, 2009
Harald Schnidar, Markus Eberl, Stefan Klingler, Doris Mangelberger, Maria Kasper, Cornelia Hauser‐Kronberger, Gerhard Regl, Renate Kroismayr, Richard Moriggl, Maria Sibilia, Fritz Aberger   +10 more
openalex   +1 more source

Genetic Mapping of Orofacial Traits Reveals a Single Genomic Region Associated With Differences in Multiple Parameters of Jaw Size Between Astyanax mexicanus Surface and Cavefish

Evolution &Development, EarlyView.
By performing a genetic association study in cave × surface fish F2 hybrids, we discovered that premaxilla width, dentary length, and maxillary length are all significantly associated with a region on Chromosome 13 containing 109 genes. ABSTRACT The regulation of bone size is a poorly understood and complex developmental process.
Amanda K. Powers, Alleigh Amaismeier, Kathryn Thiel, William Anyonge, Suzanne E. McGaugh, Tyler E. Boggs, Clifford J. Tabin, Joshua B. Gross   +7 more
wiley   +1 more source

The sonic hedgehog signaling pathway is reactivated in human renal cell carcinoma and plays orchestral role in tumor growth [PDF]

, 2009
Valérian Dormoy, Sabrina Danilin, Véronique Lindner, Lionel Thomas, Sylvie Rothhut, Catherine Coquard, Jean‐Jacques Helwig, Didier Jacqmin, Hervé Lang, Thierry Massfelder   +9 more
openalex   +1 more source

A Phase I Study of FOLFIRINOX Plus IPI-926, a Hedgehog Pathway Inhibitor, for Advanced Pancreatic Adenocarcinoma

Pancreas, 2016
A. Ko, N. Loconte, M. Tempero, E. J. Walker, R. Kate Kelley, S. Lewis, Wei-Chou Chang, Emily Kantoff, M. Vannier, D. Catenacci, A. Venook, H. Kindler   +11 more
semanticscholar   +1 more source

In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review

Epilepsia, EarlyView.
Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik, Elena Vianca, Alison Anderson, Muhammad Shahid Javaid, Terence J. O'Brien, Ana Antonic‐Baker   +5 more
wiley   +1 more source