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American Journal of Medical Genetics Part A, 2010
AbstractIn vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells.
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AbstractIn vertebrate hedgehog signaling, hedgehog ligands are processed to become bilipidated and then multimerize, which allows them to leave the signaling cell via Dispatched 1 and become transported via glypicans and megalin to the responding cells.
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Patching the gaps in Hedgehog signalling [PDF]
Nature Cell Biology, 2007 The Hedgehog (Hh) pathway plays central roles in animal development and stem-cell function. Defects in Hh signalling lead to birth defects and cancer in humans. The first and often genetically damaged step in this pathway is the interaction between two membrane proteins - Patched (Ptc), encoded by a tumour suppressor gene, and Smoothened (Smo), encoded
Rajat Rohatgi, Matthew P. Scott
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Running Interference for Hedgehog Signaling
Science Signaling, 2003The new technology of RNA interference (RNAi) is allowing high-throughput screening of cells to examine many biological processes. Michelson discusses one such system in which the Drosophila Hedgehog (Hh) pathway was analyzed by systematic genome-wide RNAi analysis. The results not only suggest unexpected overlap in
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Hedgehog signaling in skeletal development
Birth Defects Research Part C: Embryo Today: Reviews, 2006AbstractHedgehog signaling coordinates a variety of patterning processes during early embryonic development.Drosophilahedgehog and its vertebrate orthologs, Sonic hedgehog, Indian hedgehog, and Desert hedgehog, share a generally conserved signal transduction cascade.
Ehlen, H. W. A. +2 more
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Mechanisms of Hedgehog signalling in cancer
Growth Factors, 2011The Hedgehog (Hh) pathway is a conserved signalling system essential for embryonic development and for the maintenance of self-renewal pathways in progenitor cells. Mutations that deregulate Hh signalling are directly implicated in basal cell carcinoma and medulloblastoma. The mechanisms of Hh pathway activation in cancers in which no pathway mutations
Luciano G. Martelotto +3 more
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2007
TABLE OF CONTENTS Chapter 1. Purifying the Hedgehog protein and its variants by Darren P. Baker, Frederick R. Taylor and R. Blake Pepinsky Chapter 2. Application of Sonic hedgehog to the developing chick limb by Eva Tiecke and Cheryll Tickle Chapter 3.
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TABLE OF CONTENTS Chapter 1. Purifying the Hedgehog protein and its variants by Darren P. Baker, Frederick R. Taylor and R. Blake Pepinsky Chapter 2. Application of Sonic hedgehog to the developing chick limb by Eva Tiecke and Cheryll Tickle Chapter 3.
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The mechanism of hedgehog signal transduction
Biochemical Society Transactions, 2005Hedgehog (Hh) proteins are one of a small number of families of secreted signalling proteins that are responsible for cell interactions during development in many animals. As such, Hh signals produce many different responses at different times and in different cells.
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Cellular and molecular mechanisms of Hedgehog signalling
Nature Reviews Molecular Cell Biology, 2023Yunxiao Zhang, Philip A Beachy
exaly
Apatite‐Binding Nanoparticulate Agonist of Hedgehog Signaling for Bone Repair
Advanced Functional Materials, 2020Chung-sung Lee, Xiao Zhang, Jiabing Fan
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