Results 131 to 140 of about 276,693 (256)

Evaluation of a pantoprazole and 4‐desmethylpantoprazole‐sulfate metabolic ratio as a novel CYP2C19 phenotyping method

British Journal of Clinical Pharmacology, EarlyView.
Aims CYP2C19 is one of the most important pharmacogenes, and its activity is highly variable due to factors such as genetics or drug–drug interactions. Due to the lack of an appropriate endogenous CYP2C19 biomarker, surrogate methods to assess its activity are warranted.
Julian Peter Müller, Vladimir N. Belov, Sabrina Yamoune, Bob Miller, Mohammed Hasoumi, Jolanta Tupiec, Thea Laurentius, L. Cornelius Bollheimer, Julia C. Stingl, Katja S. Just   +9 more
wiley   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Allocation Mechanisms of the European Asylum, Migration and Integration Fund in Germany Raises Concerns. [PDF]

Lancet Reg Health Eur
Gold AW, Bozorgmehr K.
europepmc   +1 more source

Government Subsidies for Industrial Symbiosis: Is It Always Worth It? Assessing Effectiveness and Efficiency Through Agent‐Based Modeling

Business Strategy and the Environment, EarlyView.
ABSTRACT Policy intervention can be a driver for industrial symbiosis (IS). However, given the wide variety of policy instruments available, policymakers should be guided in the policy design process to ensure that their intervention is effective and efficient. In this paper, we propose an agent‐based (AB) model intended to assess the effectiveness and
Melissa Mollica, Alberto Nastasi, Luca Fraccascia   +2 more
wiley   +1 more source

Effects of bulevirtide on atherosclerosis in an ApoE-deficient mouse model. [PDF]

PLoS One
Rusnak J, Delcheva V, Theile D, Blank A, Frey N, Preusch MR.   +5 more
europepmc   +1 more source

Routes to Cyclobutadiene and Cycloallyl Pt(II) Complexes: Dicationic Bis(Alkyne) Species as Intermediates

Chemistry – A European Journal, EarlyView.
This work demonstrates the synthesis of cationic Pt(II) η3‐cycloallyl complexes, and experimental and computational studies show a ligand bite‐angle dependence of their formation rates. The reactivity of these complexes with Brønsted acids was investigated, leading to the formation of cationic and dicationic Pt(II) η4‐cyclobutadiene complexes ...
Ouchan He, Froze Jameel, Y. Einar H. Stampehl, Liza M. Richter, Matteo Tosi, Martin Kaupp, Thomas Braun   +6 more
wiley   +1 more source

Post‐Modification of Tripyrenylenes to Enantiopure π‐Extended D3‐Symmetric Propellers

Chemistry – A European Journal, EarlyView.
The post‐modification of tripyrenylenes to π‐extended enantiopure propellers with tris‐phenanthrophenazines is presented and the chiroptical properties as well as the solid‐state packings investigated in comparison to the corresponding racemic mixtures.
Dennis Popp, Melanie Bruttel, Sebastian Möbert, Anusha Sounder Rajan, Christoph Keck, Darius Boehm, Frank Rominger, Sven M. Elbert, Michael Mastalerz   +8 more
wiley   +1 more source

Deep molecular profiling of biliary tract cancer uncovers novel biological mechanisms and therapeutic opportunities. [PDF]

ESMO Open
Nichetti F, Hoffmeister P, Korell F, Huellein J, Uhrig S, Rübsam M, Schwab M, Teleanu MV, Jenzer M, Kreutzfeld S, Horak P, Konietzke P, Glimm H, Heining C, Rieke D, Kindler T, Springfeld C, Heilig CE, Hübschmann D, Fröhling S, Köhler BC.   +20 more
europepmc   +1 more source

Fully Reversible Regulation of 8‐17 DNAzyme Activity Using Nucleoside‐Based Diarylethenes

Chemistry – A European Journal, EarlyView.
The site‐specific incorporation of nucleosidic diarylethenes into the 8–17 deoxyribozyme (DNAzyme) identified position 2.1 as optimal. Compound dU‐PhtBu enabled efficient light‐dependent control of catalytic activity, while maintaining thermal stability and reversibility.
Jörn Bargstedt, Simon M. Büllmann, Sophia Conwell, Andres Jäschke   +3 more
wiley   +1 more source

Assessing the quality of deformable image registration in magnetic resonance image guided carbon ion liver radiotherapy with an anthropomorphic phantom. [PDF]

Phys Imaging Radiat Oncol
Pestana R, Moghaddam AB, Longarino FK, Beyer C, Qubala A, Seidensaal K, Debus J, Klüter S, Runz A, Jäkel O, Bauer J.   +10 more
europepmc   +1 more source