Results 41 to 50 of about 1,996,830 (316)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The critical height is a moduli height [PDF]

Duke Mathematical Journal, 2018
The critical height of a rational function (with algebraic coefficients) is a natural measure of dynamical complexity, essentially an adelic analogue of the Lyapunov exponent. Coordinate-free, it is well-defined on moduli space, but bears no obvious relation to the arithmetic geometry of that space as a variety.
openaire   +3 more sources

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Formation of the 32nd Guards Rifle Division and Its Participation in the Fighting in the Tuapse Direction in August 1942

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. The object of the study is the formation of the 32nd Guards Rifle Division and its participation in the fighting in the Tuapse direction in August 1942. Purpose. Identification of the features of the formation of the 32nd Guards Rifle
Sergey Kindyakov
doaj   +1 more source

The relation between adult height and haemorrhagic and ischaemic stroke in the Renfrew/Paisley study [PDF]

, 2001
Adult height is a useful marker of fetal growth, growth and nutrition in childhood and childhood infections. Studies reporting inverse associations between height and stroke therefore provide support for the hypothesis that exposures acting in early life
McCarron, PG, Hole, D.J., Hart, CL, Davey Smith, G., McCarron, P., Hart, C.L., Hole, D, Davey Smith, G   +7 more
core   +1 more source

Jumps in the Archimedean height [PDF]

Duke Mathematical Journal, 2019
We introduce a pairing on local intersection cohomology groups of variations of pure Hodge structure, which we call the asymptotic height pairing. Our original application of this pairing was to answer a question on the Ceresa cycle posed by R. Hain and D. Reed. (This question has since been answered independently by Hain.) Here we apply the pairing to
Brosnan P., Pearlstein G.
openaire   +4 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Health-related quality of life among COVID-19 survivors in Pokhara Metropolitan, Nepal: A cross-sectional study

Journal of Public Health Research
Introduction: The long-term impact of COVID-19 on Quality of Life (QoL) is a growing concern, particularly in low- and middle-income countries (LMICs) like Nepal. However, there is limited evidence on how post-COVID-19 health conditions affect daily life
Bhawana Dhakal, Dhurba Khatri, Shishir Paudel, Dipendra Kumar Yadav, Yamuna Chhetri, Shushil Tripathee, Bhakta Bahadur KC   +6 more
doaj   +1 more source