Results 41 to 50 of about 2,331,322 (315)
Journal of Public Health ResearchBackground: Tobacco use among adolescents (aged 10–19 years) remains a pressing public health concern, particularly in low-and middle-income countries like Nepal.
Sandeepa Karki +7 more
doaj +1 more source
Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношенияIntroduction. The object of the study is the formation of the 32nd Guards Rifle Division and its participation in the fighting in the Tuapse direction in August 1942. Purpose. Identification of the features of the formation of the 32nd Guards Rifle
Sergey Kindyakov
doaj +1 more source
Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Patients with chronic kidney disease undergoing hemodialysis commonly experience reduced physical function, fatigue, poor sleep quality, and impaired health‐related quality of life. Intradialytic exercise has been proposed as a non‐pharmacological strategy to improve these outcomes.
Klebson da Silva Almeida +6 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Journal of Public Health ResearchIntroduction: The long-term impact of COVID-19 on Quality of Life (QoL) is a growing concern, particularly in low- and middle-income countries (LMICs) like Nepal. However, there is limited evidence on how post-COVID-19 health conditions affect daily life
Bhawana Dhakal +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Theta height and Faltings height [PDF]
Bulletin de la Société mathématique de France, 2012 Using original ideas from J.-B. Bost and S. David, we provide an explicit comparison between the Theta height and the stable Faltings height of a principally polarized abelian variety. We also give as an application an explicit upper bound on the number of K-rational points of a curve of genus g>1 over a number filed K under a conjecture of S.
openaire +3 more sources