Results 41 to 50 of about 2,267,659 (313)

Association between uric acid and height during growth hormone therapy in children with idiopathic short stature

Frontiers in Endocrinology, 2022
BackgroundSerum uric acid (UA) within appropriate levels is reported to be beneficial in patients with idiopathic short stature (ISS). This study aimed to evaluate the association between serum UA levels and height standard deviation scores (SDS) in ...
Jong Seo Yoon, Young Jun Seo, Eun Byul Kwon, Hye Jin Lee, Min Jae Kang, Il Tae Hwang   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Effectiveness of Youth-Led awareness and advocacy intervention in shaping adolescents’ attitudes toward tobacco products in Nepal: A quasi-experimental study

Journal of Public Health Research
Background: Tobacco use among adolescents (aged 10–19 years) remains a pressing public health concern, particularly in low-and middle-income countries like Nepal.
Sandeepa Karki, Dhurba Khatri, Shishir Paudel, Yamuna Chhetri, Ganesh Shetty, Prashant Khadka, Pratikshya Pandey, Bhagawan Koirala   +7 more
doaj   +1 more source

Formation of the 32nd Guards Rifle Division and Its Participation in the Fighting in the Tuapse Direction in August 1942

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения
Introduction. The object of the study is the formation of the 32nd Guards Rifle Division and its participation in the fighting in the Tuapse direction in August 1942. Purpose. Identification of the features of the formation of the 32nd Guards Rifle
Sergey Kindyakov
doaj   +1 more source

Cloud-Heights [PDF]

Science, 1887
n ...
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Health-related quality of life among COVID-19 survivors in Pokhara Metropolitan, Nepal: A cross-sectional study

Journal of Public Health Research
Introduction: The long-term impact of COVID-19 on Quality of Life (QoL) is a growing concern, particularly in low- and middle-income countries (LMICs) like Nepal. However, there is limited evidence on how post-COVID-19 health conditions affect daily life
Bhawana Dhakal, Dhurba Khatri, Shishir Paudel, Dipendra Kumar Yadav, Yamuna Chhetri, Shushil Tripathee, Bhakta Bahadur KC   +6 more
doaj   +1 more source

The relation between adult height and haemorrhagic and ischaemic stroke in the Renfrew/Paisley study [PDF]

, 2001
Adult height is a useful marker of fetal growth, growth and nutrition in childhood and childhood infections. Studies reporting inverse associations between height and stroke therefore provide support for the hypothesis that exposures acting in early life
McCarron, PG, Hole, D.J., Hart, CL, Davey Smith, G., McCarron, P., Hart, C.L., Hole, D, Davey Smith, G, P McCarron   +8 more
core   +1 more source