Results 41 to 50 of about 6,183,460 (282)
Statistical analysis of child growth data [PDF]
, 2002 The study of child growth is complex. There are many clinical questions to answer but not necessarily the statistical methodology to deal with these questions. Human growth begins at conception and continues into adult life.Argyle, Jennifercore Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.Oleg Y. Dmitrievwiley +1 more sourceClimate-growth relationships at different stem heights in silver fir and Norway spruce [PDF]
, 2012 We investigated the effect of climate on variations in annual ring-area increment along the stem of dominant silver fir (Abies alba Mill.) and Norway spruce (Picea abies (L.) Karst.) trees in the Black Forest, southwestern Germany, to test the hypothesis Bouriaud, O., van der Maaten-Theunissen, M., van der Maaten Theunissen, Marieke, Maaten-Theunissen, Marieke van der, Bouriaud, Olivier +4 morecore +1 more sourceIMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd +9 morewiley +1 more sourceA novel common variant in DCST2 is associated with length in early life and height in adulthood [PDF]
, 2014 Common genetic variants have been identified for adult height, but not much is known about the genetics of skeletal growth in early life. To identify common genetic variants that influence fetal skeletal growth, we meta-analyzed 22 genome-wide ...Freathy, R.M., A. G. Uitterlinden (7611476), Tiesler, C. M., H. Bisgaard (7626128), Gehring, U, Ang, W., Kreiner-Møller, Eskil, Liang, L, Eriksen, Patrick, Tiesler, Carla M.T., C. Medina-Gomez (7653182), Kerkhof, M., IRAS RATIA2, Niinikoski, Harri, Simpson, Angela; id_orcid, Gehring, U., Curtin, John A., D. M. Evans (7624460), V. Lindi (7653236), Dedoussis, George V, Buxton, JL, Kemp, John P, Blakemore, A.I., Barton, S.J., Barton, S., Teo, Y-Y, Raitakari, O. T., van Duijn, C. M., Uitterlinden, Andre G., A. Palotie (7632986), Mentch, F. D., Atalay, M., Hirschhorn, Joel, Dedoussis, G. V., Postma, Dirkje S., Ang, W, Lindi, V, Uitterlinden, André G, Evans, D., Lowe, W.L., Barton, SJ, T. H. Pers (7626953), Dedoussis, G., A. Bergström (5568635), Widen, E., Simpson, Angela, Joro, R., Hakonarson, Hakon, J. Ilonen (7653254), Koppelman, Gerard H, Jaddoe, Vincent W.V., Simpson, A, Jarvelin, M., Davey Smith, George, Pers, T. H., Huikari, V, Grant, SFA, Frayling, Timothy M., Taal, HR, Armstrong, Loren L., Cousminer, D. L., Uitterlinden, AG, Evans, DM, Timpson, Nicholas J, Hofman, A., Joro, Raimo, X. Estivill (7620254), van der Valk, R J, Stokholm, Jakob, Eriksson, Johan, Alves, ADC, Eriksen, P., Jaddoe, Vincent W. V., Gonzalez, J. R., Lewin, A, Boomsma, D. I., Dedoussis, GV, Hartikainen, Anna-Liisa, Jarvelin, Marjo-Riitta, Davey Smith, G., Taal, H., R. Joro (7653137), de Jongste, J., Sergeyev, E, Bustamante Pineda, Mariona, M. G. Hayes (7653119), Pennell, C.E., Smith, GD, Sunyer, J., van Duijn, CM, Rivadeneira, F, Palotie, A, Jacobsson, Bo, Chawes, B., J. N. Hirschhorn (7609139), Barton, Sheila J, Warrington, Nicole M., Jarvelin, M.R., Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Jaddoe, V., B. Chawes (7653164), Eriksson, J, W. Kiess (7653197), Sergeyev, E., Da Silva Couto Alves, A, Rodriguez, Alina,, van Duijn, C., Sebert, S., ?, ?, Lifecourse Epidemiology, Consortium, Ntalla, I., Dedoussis, George V., M. Groen-Blokhuis (7653251), Duijn, Cornelia, T. Lakka (7653233), C. E. Pennell (7653287), Pers, T., Hakonarson, H., Buxton, J., Alves, A.D.S.C., Hirschhorn, J. N., Thiering, E, van der Valk, Ralf J. P., Llop, S, Mccarthy, Mark I, A. Custovic (3516569), Kooijman, Marjolein N., Palotie, A., Holloway, J. W., M Guxens (7653107), Early, Genetics, B. Jacobsson (7653278), Tiesler, C., Jaddoe, V.W., Jacobsson, B., Chawes, Bo, Raitakari, Olli T., Myhre, R, N. J. Timpson (7608851), Horikoshi, M, Waage, J., Pers, TH, Ring, Susan M, Saw, SM, Warrington, Nicole M, van der Valk, Ralf J.P., Körner, Antje, A. Rodriguez (7653227), Sunyer, Jordi, Melbye, Mads, Stergiakouli, E, Alves, Alexessander Da Silva Couto, Freathy, Rachel M., Bergstrom, A., Holloway, J.W., Kiess, W, Huang, J, Jaddoe, VW, Tiesler, Carla M. T., Mentch, FD, Jaddoe, VWV, Bergström, A, A. Sevelsted (7653176), Hayes, M., Armstrong, LL, Kreiner-Moller, E, Grant, S. F., Jacobsson, Bo,, Hayes, M Geoffrey, Veijola, R, E. Thiering (7653128), Sevelsted, A., Pennell, Craig E, Cousminer, D.L., de Jongste, J.C., Hartikainen, A.-L., Hayes, MG, Lakka, Timo, Lowe, WL, J. A. Curtin (7653131), Ilonen, Jorma, Hayes, M. G., Feenstra, B, N. Pitkänen (7653143), Stokholm, J., A. Lewin (7653218), Newnham, J., Ilonen, J, E. Zeggini (7632767), R. J. P. van der Valk (7653101), Holloway, JW, van Duijn, C.M., St Pourcain, B, Gonzalez, Juan R., Tiesler, CM, Alves, ADSC, C. M. T. Tiesler (7653200), Eriksen, P, LS IRAS EEPI ME (Milieu epidemiologie), Ring, S.M., Curtin, John A, Armstrong, L.L., Lowe, W., Freathy, Rachel M, Franke, L, Koerner, A, R. M. Freathy (7653149), Ntalla, I, Murray, C.S., A. Da Silva Couto Alves (7653221), J. P. Bradfield (7646234), Jaddoe, Vincent WV, H. R. Taal (7653185), Kemp, J.P., Huikari, Ville, Pitkanen, Niina, Feenstra, Bjarke, Niinikoski, H., Kreiner-Møller, E, Keinanen-Kiukaanniemi, S, N. M. Warrington (7624496), Uitterlinden, A. G., V. Huikari (7644278), Lewin, Alexandra, J. L. Buxton (7653224), Atalay, M, Mentch, F.D., Armstrong, L., Tiesler, CMT, Bisgaard, H., Kerkhof, M, Kerkhof, Marjan, Buxton, J. L., Guxens, Monica, Tiesler, C.M., Teo, Yik-Ying, Bønnelykke, K., J. Waage (7653170), Ioanna Ntalla (174685), Holloway, J., Bradfield, J. P., Frayling, TM, Huang, J., Liang, Liang, H. Niinikoski (7653290), Warrington, N. M., McCarthy, M.I., Holloway, John W., E. Kreiner-Møller (7626173), Widén, E, Thiering, Elisabeth, Kooijman, M.N., Hocher, Berthold (Prof.), Murray, C. S., Jarvelin, MR, Uitterlinden, A., Knip, M., van Duijn, Cornelia M., Estivill, Xavier, Pers, Tune H., de Jongste, JC, Sevelsted, Astrid, Jarvelin, M.-R., Kooijman, M. N., W. Ang (7653239), Waage, Johannes, Postma, D. S., Stokholm, J, Curtin, J.A., Hakonarson, H, Koppelman, Gerard H., Bonnelykke, K., Saaf, Annika, S. M. Ring (7632752), J. Stokholm (7653167), Teo, Y. Y., B. Feenstra (7653266), Grant, S.F., Barton, Sheila J., C. S. Murray (7653203), M-R. Jarvelin (7653281), Kull, I, F. D. Mentch (7653161), S. Llop (7653194), Kemp, J., Evans, David M, L. L. Armstrong (7653188), Melbye, M, Bønnelykke, K, Barton, S. J., Curtin, JA, Timpson, Nicholas J., Kemp, John P., Hofman, Albert, Raitakari, O.T., Sääf, A, Pahkala, Katja, Jaddoe, V. W., Blakemore, Alexandra I, Hartikainen, A. L., Joro, R, Hirschhorn, Joel N, Custovic, A., Pahkala, K., Rodriguez, Alina, Evans, David M., W. L. Lowe (7653269), Lindi, V., M. N. Kooijman (7653104), Cousminer, Diana L, Kemp, JP, Ntalla, Ioanna, E. Sergeyev (7653275), Tiesler, Carla MT, Mccarthy, M., R. Myhre (7653134), Kull, Inger, González Ruiz, Juan Ramón, Koppelman, Gerard H.; id_orcid, J. Eriksson (7653191), Myhre, R., van der Valk, Ralf J P, Lyytikainen, Leo-Pekka, M. Horikoshi (7647380), Armstrong, Loren L, Y-Y. Teo (7653152), Mccarthy, MI, Genetic Investigation of, ANthropometric Traits Consortium, Geller, F., Curtin, J., Murray, Clare S; id_orcid, Melbye, M., Warrington, NM, Buxton, Jessica L, R. Veijola (7653146), Newnham, JP, A. Sääf (7653113), Pennell, C. E., Lyytikainen, L.-P., M. I. Mccarthy (7653296), Evans, D.M., Kooijman, M., Medina-Gomez, C, Chawes, Bo Lund Krogsgaard, Knip, M, Bonnelykke, K, Kooijman, Marjolein N, Cousminer, Diana L., Kiess, W., Lowe, William L., Hartikainen, A.L., Llop, S., Pitkanen, N., G. V. Dedoussis (7653293), Tiesler, Carla M T, Warrington, N., Freathy, R., Kooijman, Marjolein, Taal, H.R., Veijola, R., Kooijman, MN, Lakka, T, TEO, Y.-Y., Guxens Junyent, Mònica, Liang, L., Kaakinen, M, Taal, H. R., Groen-Blokhuis, Maria, Chawes, B, Horikoshi, M., Körner, A, B. St Pourcain (7653158), Sebert, S, Kaakinen, Marika, Freathy, RM, Raitakari, Olli T, Curtin, J. A., Groen-Blokhuis, M, F. Rivadeneira (7611509), Genetic Invest ANthropometric, Kreiner-Moller, Eskil, Gonzalez, J.R., Niinikoski, H, S. Keinanen-Kiukaanniemi (7653215), Hofman, Bert, J. P. Kemp (7624478), Da Silva Couto Alves, A., C. M. van Duijn (7626872), U. Gehring (7626152), Koppelman, G. H., D. S. Postma (3809164), K. Bønnelykke (7653299), Jongste, Johan, Murray, Clare S, Hartikainen, A., Lyytikainen, L-P, Saaf, A., Gonzalez, Juan R, Grallert, H., van der Valk, R. J., Palotie, Aarno, Pers, T.H., Zeggini, E, Sergeyev, Elena, Teo, Y., Korner, A., Hartikainen, AL, I. Kull (3516731), Early Genetics Lifecourse, M. Knip (7653260), Early Growth Genetics, Consortium, Uitterlinden, André, Gonzalez, JR, H. Grallert (4107469), Lindi, Virpi, Teo, YY, G. H. Koppelman (3809212), Bustamante, Mariona, S. J. Barton (7653155), St Pourcain, Beate, Smith, G.D., Grant, S.F.A., Frayling, T., McCarthy, M. I., Stergiakouli, E., Newnham, John P., Zeggini, Eleftheria, Hocher, Berthold, Murray, C., Saw, S. M., Eriksson, J., Ang, Wei, A. I. Blakemore (7652759), Hayes, M.G., S. F. A. Grant (7653263), Sunyer, J, Grant, Struan F A, Lyytikäinen, LP, Mccarthy, Mark I., Rivadeneira, Fernando, Huang, Jinyan, Magnus, P, Sengpiel, Verena,, Buxton, Jessica L., Grallert, Harald, Risk Assessment, Jarvelin, M-R, Groen-Blokhuis, M.M., Knip, Mikael, Raitakari, O., Blakemore, AI, Bisgaard, Hans, L. Liang (6079640), Guxens, M, Da Silva Couto Alves, Alexessander, V. W. V. Jaddoe (7653302), Teo, Y.Y., Gonzalez, J., Warrington, N.M., Simpson, A., Widen, Elisabeth, Raitakari, OT, Bisgaard, H, Franke, Lude, Lakka, T., Koerner, Antje, Rodriguez, A, Pennell, Craig E., de Jongste, J. C., de Jongste, Johan C., Tiesler, C.M.T., Grant, Struan F.A., Blakemore, A., M. Vaarasmaki (7653230), Lewin, A., P. Magnus (3570941), Bustamante, M., Jarvelin, M. R., Davey Smith, G, E. Stergiakouli (7653110), Veijola, Riitta, Murray, Clare S., de Jongste, Johan C, Cousminer, DL, Mahajan, A, Dedoussis, G.V., A. Simpson (7653206), E. Widén (7653272), van der Valk, R.J.P., Jaddoe, Vincent W V, Grant, Struan F. A., D. L. Cousminer (7653122), Atalay, Mustafa, Flexeder, Claudia, Blakemore, A. I., Frayling, Timothy M, Boomsma, D.I.; id_orcid, C. Flexeder (7626146), Estivill, Xavier, 1955-, Timpson, N. J., A-L. Hartikainen (7653212), Bradfield, J.P., Ring, S., Hayes, M. Geoffrey, Timpson, NJ, F. Geller (7653116), Boomsma, Dorret I, Grant, S., Buxton, J.L., St Pourcain, B., Cousminer, D., Pennell, CE, M. Bustamante (2906126), Boomsma, D., Holloway, John W, Bradfield, JP, van der Valk, RJP, H. Hakonarson (7609127), Hocher, B, Armstrong, L. L., Uitterlinden, André; id_orcid, Mentch, F., Postma, Dirkje S, Keinanen-Kiukaanniemi, Sirkka, Early Growth Genetics (EGG) Consortium, Ring, SM, Rivadeneira, F., Bradfield, Jonathan P, K. Panoutsopoulou (7632989), Feenstra, B., M. Kerkhof (7653140), Genetic Investigation of ANthropometric Traits (GIANT) Consortiu, Sengpiel, V., Smith, George Davey, Postma, D.S., Mentch, Frank D., Sunyer Deu, Jordi, Boomsma, Dorret I., Hirschhorn, J.N., Medina-Gomez, Carolina, E. Melén (3494549), M. Atalay (7653284), Saw, S., van der Valk, R., Vaarasmaki, M., Medina-Gomez, C., Blakemore, Alexandra I., Hocher, B., L-P. Lyytikäinen (7653245), Sengpiel, V, Evans, D. M., Waage, J, van der Valk, R.J., Kaakinen, M., Flexeder, C, Panoutsopoulou, K, Geller, F, Saw, S.-M., Murray, CS, Sengpiel, Verena, Early Growth Genetics EGG, Koppelman, G., Guxens, M., Jacobsson, B, van der Valk, RJ, Rodriguez, A., Lyytikainen, L. P., Valk, Ralf, Taal, Rob; id_orcid, Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium, Llop, Sabrina, Sebert, Sylvain, D. I. Boomsma (1812745), Kiess, Wieland, Koppelman, GH, Timpson, N., Boomsma, DI, Grant, SF, Pers, Tune H, Custovic, Adnan, Pennell, C., Grant, Struan FA, Mahajan, A., Newnham, John P, Jaddoe, Vincent, Ring, S. M., Uitterlinden, A.G., Saw, Seang-Mei, Blakemore, Alexandra I. F., Pers, Tune Hannes, Ilonen, J., Koppelman, G.H., Kull, I., S. Sebert (7626812), Estivill, X., Franke, L., Estivill, X, Hirschhorn, J., Jaddoe, V.W.V., Sevelsted, A, Myhre, Ronny, Koerner, A., Lowe, William L, Stergiakouli, Evangelia, A. Körner (7653125), Gehring, Ulrike, Bonnelykke, Klaus, Geller, Frank, Hartikainen, A-L, Zeggini, E., van der Valk, Ralf JP, J. Sunyer (3516257), Mentch, Frank D, Hirschhorn, Joel N., Taal, H Rob, Vaarasmaki, M, Melen, Erik, Seang-Mei Saw (159451), Liang, Liming, Thiering, E., J. Huang (2342368), L. Franke (7602401), Boomsma, D.I., T. M. Frayling (7608959), Hofman, A, Bradfield, Jonathan P., A. Hofman (4269889), P. Eriksen (7653173), Bustamante, M, Postma, D., J. W. Holloway (7611494), Kerkhof, Marjon, Melén, E, J. C. de Jongste (7626116), Frayling, T.M., Panoutsopoulou, K., M. Melbye (7653179), Taal, H. Rob, Huikari, V., Grallert, H, K. Pahkala (7653248), Ring, Susan M., J. P. Newnham (7653242), Pitkänen, N, Lyytikainen, L., Bradfield, J., Custovic, A, Bønnelykke, Klaus, Magnus, P., Vaarasmaki, Marja, Groen-Blokhuis, M., Postma, DS, Melen, E., Lowe, W. L., Newnham, J. P., Keinanen-Kiukaanniemi, S., B. Hocher (7653257), Kreiner-Moller, E., Newnham, J.P., J. R. Gonzalez (7606541), A. Mahajan (7603748), Kemp, J. P., Hirschhorn, JN, M. Kaakinen (7626740), Kreiner-Møller, E., van Duijn, Cornelia M, G. D. Smith (4912390), Bergstrom, Anna, Magnus, Per, Pahkala, K, Panoutsopoulou, Kalliope, V. Sengpiel (7653209), Flexeder, C., Taal, Rob, Timpson, N.J., Mahajan, Anubha, O. T. Raitakari (7647452), Saw, S-M, Horikoshi, Momoko, Saw, S.M., van, der Valk RJP +680 morecore +4 more sourcesIn vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer +8 morewiley +1 more sourceHeight and risk of death among men and women: aetiological implications of associations with cardiorespiratory disease and cancer mortality [PDF]
, 2000 OBJECTIVES: Height is inversely associated with cardiovascular disease mortality risk and has shown variable associations with cancer incidence and mortality.Upton, M., Davey Smith, G., Watt, G., Hart, C.L., Gillis, C.R., Hawthorne, V.M. +5 morecore +1 more source
