Synchronized Imaging of Hydrogen Peroxide and Hydroxyl Radical in Pyroptosis and Epilepsy
Advanced Science, EarlyView.A dual‐responsive fluorescent probe, HH, enables synchronized visualization of H2O2 and •OH through spectrally resolved green and red channels. By tracking redox dynamics in pyroptosis and epilepsy models, HH reveals ROS elevation during seizure‐like pathology and supports evaluation of antioxidant and antiepileptic therapeutic interventions.
Yabing Gan +9 more
wiley +1 more source
Enhanced Anticancer Activity of Ibuprofen and 2'-Hydroxy-2,3,5'-trimethoxychalcone-Linked Polymeric Micelles in HeLa Cells. [PDF]
ACS OmegaBaek S +7 more
europepmc +1 more source
Programmable Nanobody‐Targeting Chimeras Enable Intracellular Viral Protein Degradation
Advanced Science, EarlyView.Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Max Yu‐Chen Pan +11 more
wiley +1 more source
Synergistic cytotoxicity of recombinant IGFBP-3 and cisplatin in HPV18-positive HeLa cells <i>via</i> NF-κB inflammatory modulation. [PDF]
Res Pharm SciArab H +3 more
europepmc +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source
From Functional Food to Therapeutic Prospect: Mechanistic Study of Gypenoside XVII in HeLa Cells. [PDF]
MoleculesHussain SS +4 more
europepmc +1 more source
ALKALINE PHOSPHATASE ACTIVITY IN HELA CELLS [PDF]
Journal of Histochemistry & Cytochemistry, 1967 J, Hugon, M, Borgers, M C, Loni
openaire +2 more sources
Engineering a 660 nm‐Responsive Optogenetic Inducer of Pyroptosis for Precision Cancer Therapy
Advanced Science, EarlyView.This study reports a bioorthogonal pyroptosis inducer, PyroRACS. By using a red‐light‐responsive Cre‐On genetic switch to control the expression of highly cytotoxic GSDMDNT, PyroRACS enables the artificial induction of pyroptosis with precise spatiotemporal control.
Mengkai Zhang +5 more
wiley +1 more source
Bioactive Aromatic Plant Extracts Modulate Metabolism and Inflammation in HeLa Cells. [PDF]
MoleculesSilva S, Machado M, Pintado M, Costa EM.
europepmc +1 more source
Chromatin Packing Domain Engineering Through the Manipulation of Nuclear Cationic States
Advanced Science, EarlyView.Manipulation of intranuclear divalent cation concentrations rapidly and reversibly remodels chromatin packing domains in living cells. Magnesium depletion disrupts domain compaction, heterochromatin organization, and transcriptional regulation, whereas magnesium loading promotes more compact and stable domains.
Cody L. Dunton +13 more
wiley +1 more source