Results 41 to 50 of about 213,518 (194)
Seismic Performance of Grouped Helical Piles in Pinned and Fixed Connections [PDF]
, 2018 Helical piles have yet to be nationally considered an acceptable foundation for structures in areas of high seismic activity. This remains despite evidence of helical pile survival stories from recent earthquakes where other foundations failed, and ...
Allred, Shawn
core
The thermal behaviour of three different auger pressure grouted piles used as heat exchangers [PDF]
, 2014 Three auger pressure grouted (APG) test piles were constructed at a site in Richmond, Texas. The piles were each equipped with two U-loops of heat transfer pipes so that they could function as pile heat exchangers.
Brettmann, T +11 more
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
G-Functions for multiple interacting pile heat exchangers [PDF]
, 2014 Pile heat exchangers – where heat transfer pipes are cast into the building piled foundations – offer an opportunity to use ground energy systems without the additional construction costs related to the provision of special purpose heat exchangers ...
Loveridge, F.A. +3 more
core +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Seismic soil pile interaction:experimental evidence [PDF]
, 2009 The comprehension of the real behaviour of pile foundations under earthquake loading is very important, since it can significantly affect the performance of the superstructure.
Moccia, Flaviana
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Journal of the Civil Engineering ForumThe methods employed to calculate the axial bearing capacity of a helical pile depends on the shear failure model around the pile, which is also influenced by the spacing and diameter of the helical plates.
Ignatius Tommy Pratama +2 more
doaj +1 more source