Results 51 to 60 of about 203,810 (284)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The behaviour of laterally loaded two-pile groups [PDF]

, 1992
The response of piles and two-pile groups to lateral loading has been studied by field tests and computationally. Due to the lack of field test data and because of uncertainty concerning the pile/soil system it has been suggested that further ...
Arta, M.R., Arta, Mahmood Reza
core  

COMPRESSIVE CAPACITY OF HELICAL PILE FOUNDATION ON PEAT WITH VARIATION OF HELICAL PLATE DIAMETER

astonjadro, 2021
<p>The use of helical foundations to support structures on peat soil is still a new method. Research is needed to develop this foundation. There are 6 types of helical foundation tested on peat soil. To study the effect of helical plate diameter, plate diameters were varied with sizes 25 cm (M), 35 cm (L), and 45 cm (G).
Sapria Adi, Ferry Fatnanta, Syawal Satibi   +2 more
openaire   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Numerical Study on the Effects of Helix Diameter and Spacing on the Helical Pile Axial Bearing Capacity in Cohesionless Soils

Journal of the Civil Engineering Forum
The methods employed to calculate the axial bearing capacity of a helical pile depends on the shear failure model around the pile, which is also influenced by the spacing and diameter of the helical plates.
Ignatius Tommy Pratama, Anastasia Sri Lestari, Ivan Oktavianus   +2 more
doaj   +1 more source

Rotational and Penetration Rate Effects on the Formation and Axial Capacity of Pressure-Grouted Helical Piles [PDF]

E3S Web of Conferences
The Pressure Grouted Helical Pile (PGHP) is an innovative composite foundation system built in one step by combining the structural stiffness of a helical shaft and the deformability of a cement treated pile body.
Wang Qiang, Yang Fu, Fang Shuai, Yang Yucun, Zhang Wei, Zhang Jinlong   +5 more
doaj   +1 more source

Experimental Modelling of Helical Piles Subjected to Axial Loading

International Journal of Emerging Engineering and Technology, 2023
In the construction sector, axial loads have traditionally been supported by piles. There hasn't been sufficient comparative study related to the economics and viability aspects of conventional and helical piles up to this point in natural soil ...
Hazrat Bilal, Muhammad Alam, Muhammad Sarir, Abdul Hameed Khan, Muhammad Safdar, Hamza Ahmad Qureshi   +5 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source