Results 101 to 110 of about 234,919 (306)

Beyond Gut Modulation: A Critical Review of the Therapeutic Potential, Safety, and Clinical Prospects of Natural Polysaccharides for IBD

Food Safety and Health, EarlyView.
In this review, we critically summarized the application of natural polysaccharides (NPs) for the treatment of IBD. This approach combines, in a unique way (right), the basic structure–activity relationships of NPs from different origins (left) with their multipronged mode of action, which involves modulation of the gut microbiota and other ...
Felix Danso, A. M. Abd El‐Aty, Kwaku Amoah, Xianghong Ju   +3 more
wiley   +1 more source

bacNeo: A Computational Toolkit for Identifying Bacteria‐Derived Neoantigens in Human Cancers

iMetaMed, EarlyView.
We present bacterial neoantigen (bacNeo), a multi‐omics‐based computational software to classify bacterial components (BACC), type bacteria‐bound HLA alleles (BACH), and prioritize bacterial peptides as neoantigens (BACP). Bacterial neoantigen potential is quantified by score for peptide antigenicity recognition & kinetics (SPARK), enabling ...
Yunzhe Wang, Li Yuan, Katie W. Gu, Xiangdong Cheng, Bo Wen, Zhao Zhang   +5 more
wiley   +1 more source

Metabolomic and lipidomic signatures of Helicobacter pylori infection: Unveiling biochemical pathways associated with neurodegeneration

iMetaOmics, EarlyView.
Our study employed an integrated lipidomics and metabolomics approach to elucidate Helicobacter pylori‐driven metabolic perturbations along the gut–brain axis. H. pylori infection was established in gastric epithelial (AGS) cells, and the resulting conditioned media (secretome) was collected and exposed to neuronal (IMR‐32) cells.
Meenakshi Kandpal, Tarun Prakash Verma, Siddharth Singh, Hamendra Parmar, Hem Chandra Jha   +4 more
wiley   +1 more source

Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans [PDF]

, 2012
Peer ...
Alberto Delgado, Amieva, Argent, Barrett, Cathy Streutker, Dana J. Philpott, Deepa Raju, Deretic, El-Omar, Emad El Omar, Erdmutte Kunstmann, Esther Galindo–Mata, Franco, Georgina Hold, Gonzalez, Gutierrez, Heidi Mascarenhas, Iwamaru, Jia, Judith Romero–Gallo, Kimura, Kirkegaard, Kuballa, Lapaquette, Levine, Luther, Luther, Mahendra Singh Ramjeet, Maiuri, Mark S. Silverberg, Mathew, Mathew, Mauricio R. Terebiznik, Michal Sibony, Michelle Ang, Mortimore, Moscat, Nicola L. Jones, Ogawa, Ogawa, Orvedahl, Pelayo Correa, Polk, Richard M. Peek, Rioux, Saitoh, Satin, Scott, Seamus Hussey, Stephen E. Girardin, Steven R. Blanke, Tamotsu Yoshimori, Tanida, Terebiznik, Terebiznik, Travassos, Vijay Gupta, Wang, White, Yoshimori, Zheng, Zheng   +61 more
core   +1 more source

Socioeconomic Status Modifies the Risk of Gastric Cancer Through Metabolomic Signature: Evidence From a Prospective Cohort Study

iNew Medicine, EarlyView.
ABSTRACT The role of metabolites in the association between socioeconomic status (SES) and gastric cancer remains unclear. This study seeks to elucidate the role of metabolomics in the association between SES and gastric cancer, as well as to explore potential interactions between metabolic signatures and polygenic risk score (PRS) in the context of ...
Shiyin Meng, Shangxin Zhang, Jing Wang, Zhuoyi Wu, Wenjie Xuan, Jiawei Zhang, Qihong Zhao, Anla Hu, Jing Ni   +8 more
wiley   +1 more source

Assessment and analysis of H.pylori infection treatment strategies of St. Vincent Hospital\u27s family and internal medicine clinics [PDF]

, 2019
Helicobacter pylori is a gram-negative bacteria that is responsible for causing chronic gastritis, ulcers in the stomach and intestine, and eventually even gastric lymphoma or cancer.
Orr, Rebecca
core   +1 more source

Peptic ulcer disease: Insights and risk factors

JPGN Reports, EarlyView.
Abstract Objectives Peptic ulcer disease (PUD), affects adults and children, with Helicobacter pylori (H. pylori) infection being the most frequent cause. Diagnosis requires an upper gastrointestinal endoscopy (UGE) and invasive tests. However, besides H. pylori, risk factors for PUD in children remain unclear.
Haidar Houmani, Islam Saidi, Meline M'rini, Julie Nguyen, Assaad Salame, Patrick Bontems, Kallirroi Kotilea   +6 more
wiley   +1 more source

Helicobacter pylori infection is associated with an increased rate of diabetes. [PDF]

, 2012
ObjectiveChronic infections could be contributing to the socioeconomic gradient in chronic diseases. Although chronic infections have been associated with increased levels of inflammatory cytokines and cardiovascular disease, there is limited evidence on
Aiello, Allison E, Cheng, Caroline, Clayton, Erin R, Haan, Mary N, Jeon, Christie Y, Mayeda, Elizabeth R, Miller, Joshua W   +6 more
core   +1 more source

Gastric duplication cyst causing hypergastrinemia in an infant

JPGN Reports, EarlyView.
Abstract Gastric duplication cysts are rare congenital anomalies, with fewer than 10% occurring in the stomach. We report a 14‐month‐old girl presenting with failure to thrive, recurrent emesis, hematemesis, and severe duodenitis with ulceration. Laboratory evaluation revealed marked hypergastrinemia (1781 pg/mL), and initial imaging was unrevealing ...
Nathan Bryan, Ian Leibowitz
wiley   +1 more source

Impact of Maternal Helicobacter pylori Infection on Trace Elements (Copper, Iron and Zinc) and Pregnancy Outcomes [PDF]

, 2010
Background: H. pylori infection has been suggested to interfere with micronutrient metabolism and influence pregnancy outcomes. Objectives: This study therefore seeks to document the prevalence of H.
Akubugwo, EI, Ugwuja, EI
core